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Catalano, CalogerinaGerman Cancer Research Centre
(author)
Short article : Influence of regulatory NLRC5 variants on colorectal cancer survival and 5-fluorouracil-based chemotherapy
- Article/chapterEnglish2018
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LIBRIS-ID:oai:lup.lub.lu.se:561c6817-c639-44da-bb2d-599288fab658
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https://lup.lub.lu.se/record/561c6817-c639-44da-bb2d-599288fab658URI
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https://doi.org/10.1097/MEG.0000000000001154DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
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Background NLRC5 is an interferon γ-inducible protein, which plays a role in immune surveillance with a potential influence on cancer survival. Objective We aimed to evaluate the effect of potential regulatory variants in NLRC5 on overall survival and survival after 5-fluorouracil (5-FU)-based therapy of colorectal cancer (CRC) patients. Patients and methods We carried out a case-only study in a Czech population of 589 cases; 232 received 5-FU-based therapy. Eleven variants within NLRC5 were selected using in-silico tools. Associations between polymorphisms and survival were assessed by Cox regression analysis adjusting for age at diagnosis, sex, and TNM stage. Survival curves were derived using the Kaplan-Meier method. Results Two variants showed a significant association with survival. All patients and metastasis-free patients at the time of diagnosis (pM0) who were homozygous carriers of the minor allele of rs27194 had a decreased overall survival (OS all and OS pM0) and event-free survival (EFS pM0) under a recessive model (OS all P=0.003, OS pM0 P=0.005, EFS pM0 P=0.01, respectively). OS was also decreased for all patients and for pM0 patients who carried at least one minor allele of rs289747 (OS all P=0.03 and OS pM0 P=0.003, respectively). Among CRC patients, who underwent a 5-FU-based adjuvant regimen, rs12445252 was associated with OS all, OS pM0 and EFS pM0, according to the dosage of the minor allele T (OS all P=0.0004, OS pM0 P=0.0001, EFS pM0 P=0.008, respectively). Conclusion Our results showed that polymorphisms in NLRC5 may be used as prognostic markers of survival of CRC patients, as well as for survival in response to 5-FU treatment.
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Da Silva Filho, Miguel I.German Cancer Research Centre(Swepub:lu)med-md_
(author)
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Jiraskova, KaterinaCharles University in Prague,Academy of Sciences of the Czech Republic
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Vymetalkova, VeronikaAcademy of Sciences of the Czech Republic,Charles University in Prague
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Levy, MiroslavCharles University in Prague
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Liska, VaclavCharles University in Prague
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Vycital, OndrejCharles University in Prague
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Naccarati, AlessioAcademy of Sciences of the Czech Republic
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Vodickova, LudmilaAcademy of Sciences of the Czech Republic,Charles University in Prague
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Hemminki, KariLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,German Cancer Research Centre(Swepub:lu)med-khk
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Vodicka, PavelCharles University in Prague,Academy of Sciences of the Czech Republic
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Weber, Alexander N.R.University of Tübingen
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Försti, AstaLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,German Cancer Research Centre(Swepub:lu)med-asf
(author)
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German Cancer Research CentreCharles University in Prague
(creator_code:org_t)
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In:European Journal of Gastroenterology and Hepatology30:8, s. 838-8420954-691X
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