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Cysteinyl leukotrie...
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Savari, SayehKarolinska Institutet,Lund University,Lunds universitet,Cellpatologi, Malmö,Forskargrupper vid Lunds universitet,Cell Pathology, Malmö,Lund University Research Groups,Skåne University Hospital
(författare)
Cysteinyl leukotriene 1 receptor influences intestinal polyp incidence in a gender-specific manner in the ApcMin/+ mouse model
- Artikel/kapitelEngelska2016
Förlag, utgivningsår, omfång ...
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2016-03-15
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Oxford University Press (OUP),2016
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:5661ddbc-160d-431f-b17d-f80cc7a8be4d
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https://lup.lub.lu.se/record/5661ddbc-160d-431f-b17d-f80cc7a8be4dURI
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https://doi.org/10.1093/carcin/bgw031DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:133566639URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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There is emerging literature emphasizing the role of inflammatory eicosanoids, including prostaglandins and leukotrienes, in cancer development. Increased expression of both the cysteinyl leukotriene receptor 1 (CysLTR1) and the enzyme responsible for the production of leukotrienes, 5-lipoxygenase (5-LOX), is associated with poor prognosis in patients with colorectal adenocarcinomas. Apc mutation is an early event in the development of sporadic and hereditary (FAP) colorectal cancer. We utilized the Apc(Min/+) mouse model of FAP/sporadic colorectal cancer to investigate the role of CysLTR1 in intestinal tumorigenesis by crossing Apc(Min/+) mice with mice lacking the Cysltr1 gene. We could observe a reduced tumor burden in the small intestine of double-mutant female (Cysltr1(-/-) Apc(Min/+)) but not double-mutant male mice, compared to gender-matched single-mutant (Cysltr1(+/+) Apc(Min/+)) mice. This reduction was in a Cysltr1 dependent manner, female double mutant mice having significantly reduced tumor formation compared to control littermates. The female double-mutant phenotype was accompanied with decreased systemic inflammation, as evidenced by significantly reduced serum levels of PGE2 and CysLTs, as well as increased CD3(+)CD8(+) T cell tumor infiltration. Furthermore, the reduced formation of polyps in double-mutant (Cysltr1(-/-) Apc(Min/+)) female mice could in part be explained by the cytotoxic action of CD3(+)CD8(+) T cells in the polyp and reduced nuclear accumulation of β-catenin in the epithelium of small intestinal polyps. Our results stress the important role that CysLTR1 plays in colorectal cancer and its potential as a therapeutic target in cancer therapy.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Chandrashekar, Naveen Kumar
(författare)
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Osman, JaninaLund University,Lunds universitet,Cellpatologi, Malmö,Forskargrupper vid Lunds universitet,Cell Pathology, Malmö,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-jao
(författare)
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Douglas, DesireeLund University,Lunds universitet,Cellpatologi, Malmö,Forskargrupper vid Lunds universitet,Cell Pathology, Malmö,Lund University Research Groups,Skåne University Hospital(Swepub:lu)cob-ddo
(författare)
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Bellamkond, Kishan
(författare)
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Jönsson, GunillaLund University,Lunds universitet,Cellpatologi, Malmö,Forskargrupper vid Lunds universitet,Cell Pathology, Malmö,Lund University Research Groups,Skåne University Hospital(Swepub:lu)wbl-gjo
(författare)
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Juhas, MariaLund University,Lunds universitet,Cellpatologi, Malmö,Forskargrupper vid Lunds universitet,Cell Pathology, Malmö,Lund University Research Groups,Skåne University Hospital(Swepub:lu)expp-mju
(författare)
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Greicius, GediminasKarolinska Institute,National Cancer Centre Singapore
(författare)
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Pettersson, SvenKarolinska Institute,National Cancer Centre Singapore
(författare)
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Sjölander, AnitaLund University,Lunds universitet,Cellpatologi, Malmö,Forskargrupper vid Lunds universitet,Cell Pathology, Malmö,Lund University Research Groups,Skåne University Hospital(Swepub:lu)expp-asj
(författare)
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Cellpatologi, MalmöForskargrupper vid Lunds universitet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Carcinogenesis: Oxford University Press (OUP)37:5, s. 491-4990143-33341460-2180
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Till lärosätets databas
- Av författaren/redakt...
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Savari, Sayeh
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Chandrashekar, N ...
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Osman, Janina
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Douglas, Desiree
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Bellamkond, Kish ...
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Jönsson, Gunilla
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visa fler...
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Juhas, Maria
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Greicius, Gedimi ...
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Pettersson, Sven
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Sjölander, Anita
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Cell och molekyl ...
- Artiklar i publikationen
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Carcinogenesis
- Av lärosätet
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Lunds universitet
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Karolinska Institutet