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Sökning: id:"swepub:oai:lup.lub.lu.se:5661ddbc-160d-431f-b17d-f80cc7a8be4d" > Cysteinyl leukotrie...

  • Savari, SayehKarolinska Institutet,Lund University,Lunds universitet,Cellpatologi, Malmö,Forskargrupper vid Lunds universitet,Cell Pathology, Malmö,Lund University Research Groups,Skåne University Hospital (författare)

Cysteinyl leukotriene 1 receptor influences intestinal polyp incidence in a gender-specific manner in the ApcMin/+ mouse model

  • Artikel/kapitelEngelska2016

Förlag, utgivningsår, omfång ...

  • 2016-03-15
  • Oxford University Press (OUP),2016

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:5661ddbc-160d-431f-b17d-f80cc7a8be4d
  • https://lup.lub.lu.se/record/5661ddbc-160d-431f-b17d-f80cc7a8be4dURI
  • https://doi.org/10.1093/carcin/bgw031DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:133566639URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • There is emerging literature emphasizing the role of inflammatory eicosanoids, including prostaglandins and leukotrienes, in cancer development. Increased expression of both the cysteinyl leukotriene receptor 1 (CysLTR1) and the enzyme responsible for the production of leukotrienes, 5-lipoxygenase (5-LOX), is associated with poor prognosis in patients with colorectal adenocarcinomas. Apc mutation is an early event in the development of sporadic and hereditary (FAP) colorectal cancer. We utilized the Apc(Min/+) mouse model of FAP/sporadic colorectal cancer to investigate the role of CysLTR1 in intestinal tumorigenesis by crossing Apc(Min/+) mice with mice lacking the Cysltr1 gene. We could observe a reduced tumor burden in the small intestine of double-mutant female (Cysltr1(-/-) Apc(Min/+)) but not double-mutant male mice, compared to gender-matched single-mutant (Cysltr1(+/+) Apc(Min/+)) mice. This reduction was in a Cysltr1 dependent manner, female double mutant mice having significantly reduced tumor formation compared to control littermates. The female double-mutant phenotype was accompanied with decreased systemic inflammation, as evidenced by significantly reduced serum levels of PGE2 and CysLTs, as well as increased CD3(+)CD8(+) T cell tumor infiltration. Furthermore, the reduced formation of polyps in double-mutant (Cysltr1(-/-) Apc(Min/+)) female mice could in part be explained by the cytotoxic action of CD3(+)CD8(+) T cells in the polyp and reduced nuclear accumulation of β-catenin in the epithelium of small intestinal polyps. Our results stress the important role that CysLTR1 plays in colorectal cancer and its potential as a therapeutic target in cancer therapy.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Chandrashekar, Naveen Kumar (författare)
  • Osman, JaninaLund University,Lunds universitet,Cellpatologi, Malmö,Forskargrupper vid Lunds universitet,Cell Pathology, Malmö,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-jao (författare)
  • Douglas, DesireeLund University,Lunds universitet,Cellpatologi, Malmö,Forskargrupper vid Lunds universitet,Cell Pathology, Malmö,Lund University Research Groups,Skåne University Hospital(Swepub:lu)cob-ddo (författare)
  • Bellamkond, Kishan (författare)
  • Jönsson, GunillaLund University,Lunds universitet,Cellpatologi, Malmö,Forskargrupper vid Lunds universitet,Cell Pathology, Malmö,Lund University Research Groups,Skåne University Hospital(Swepub:lu)wbl-gjo (författare)
  • Juhas, MariaLund University,Lunds universitet,Cellpatologi, Malmö,Forskargrupper vid Lunds universitet,Cell Pathology, Malmö,Lund University Research Groups,Skåne University Hospital(Swepub:lu)expp-mju (författare)
  • Greicius, GediminasKarolinska Institute,National Cancer Centre Singapore (författare)
  • Pettersson, SvenKarolinska Institute,National Cancer Centre Singapore (författare)
  • Sjölander, AnitaLund University,Lunds universitet,Cellpatologi, Malmö,Forskargrupper vid Lunds universitet,Cell Pathology, Malmö,Lund University Research Groups,Skåne University Hospital(Swepub:lu)expp-asj (författare)
  • Cellpatologi, MalmöForskargrupper vid Lunds universitet (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Carcinogenesis: Oxford University Press (OUP)37:5, s. 491-4990143-33341460-2180

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