Contact dermatitis caused by a new rubber compound detected in canvas shoes

BACKGROUND: In 2015 and 2016, female patients in Flanders consulted a dermatologist because they developed skin lesions after wearing a specific brand of canvas shoes.OBJECTIVES: To identify the culprit allergen in the shoes.METHODS: Eighteen young females aged 14-22 years presented with itching and erythematous to purple-coloured eczematous lesions on both feet. They were patch tested by 10 dermatologists with the European baseline series. Some patients underwent testing with additional series. Pieces of the shoe fabrics were tested in 11 of 18 patients. Chemical analysis of the shoe materials was performed. Finally, patients were tested with a thin-layer chromatogram of the shoe extracts and dilutions of the suspected rubber compound.RESULTS: All 18 patients showed positive reactions to thiuram mix. Ten of 11 patients reacted to a piece of shoe fabric. Chemical analysis showed the presence of dimethylthiocarbamylbenzothiazole sulfide (DMTBS). No thiurams were detected. Four patients tested with the chromatogram developed positive reactions to DMTBS. Positive reactions to low concentrations were observed in the 4 patients tested with a DMTBS dilution series; one patient reacted to 0.00001% in acetone.CONCLUSIONS: DMTBS, the culprit allergen, is a component formed during rubber vulcanization that probably cross-reacts with the thiuram mix.

Bergendorff, OlaLund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)derm-obe (författare)
Persson, ChristinaLund University,Lunds universitet,Dermatologi och venereologi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Dermatology and Venereology (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)mphy-csv (författare)
Goossens, AnUniversity Hospitals Leuven (författare)
Gilissen, LiesbethUniversity Hospitals Leuven (författare)
Engfeldt, MalinLund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)derm-mfr (författare)
Bruze, MagnusLund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)derm-mbr (författare)
Schuttelaar, Marie LUniversity Medical Center Groningen (författare)
Meijer, Joost MUniversity Medical Center Groningen (författare)
Lapeere, HildeGhent University Hospital (författare)
Ghent University HospitalYrkes- och miljödermatologi (creator_code:org_t)

Av författaren/redakt...: Hulstaert, Eva; Bergendorff, Ola; Persson, Christi ...; Goossens, An; Gilissen, Liesbe ...; Engfeldt, Malin; visa fler...; Bruze, Magnus; Schuttelaar, Mar ...; Meijer, Joost M; Lapeere, Hilde; visa färre...

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