Sökning: WFRF:(Alarcón Graciela S.)
> (2020-2024) >
Lower vitamin D is ...
Lower vitamin D is associated with metabolic syndrome and insulin resistance in systemic lupus : Data from an international inception cohort
-
- Chew, Christine (författare)
- University of Manchester
-
- Reynolds, John A. (författare)
- University of Birmingham
-
- Lertratanakul, Apinya (författare)
- Northwestern University Feinberg School of Medicine
-
visa fler...
-
- Wu, Peggy (författare)
- Northwestern University Feinberg School of Medicine
-
- Urowitz, Murray (författare)
- Toronto Western Hospital
-
- Gladman, Dafna D. (författare)
- Toronto Western Hospital
-
- Fortin, Paul R. (författare)
- Laval University
-
- Bae, Sang Cheol (författare)
- Hanyang University Medical Center
-
- Gordon, Caroline (författare)
- University of Birmingham
-
- Clarke, Ann E. (författare)
- Cumming School of Medicine
-
- Bernatsky, Sasha (författare)
- McGill University
-
- Hanly, John G. (författare)
- Dalhousie University
-
- Isenberg, David (författare)
- University College London
-
- Rahman, Anisur (författare)
- University College London
-
- Sanchez-Guerrero, Jorge (författare)
- Toronto Western Hospital
-
- Romero-Diaz, Juanita (författare)
- Salvador Zubirán National Institute of Health Sciences and Nutrition
-
- Merrill, Joan (författare)
- Oklahoma Medical Research Foundation
-
- Wallace, Daniel (författare)
- University of California, Los Angeles
-
- Ginzler, Ellen (författare)
- SUNY Downstate Health Sciences University
-
- Khamashta, Munther (författare)
- King's College London
-
- Nived, Ola (författare)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
-
- Jönsen, Andreas (författare)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
-
- Steinsson, Kristjan (författare)
- National University Hospital of Iceland
-
- Manzi, Susan (författare)
- Allegheny Health Network
-
- Kalunian, Ken (författare)
- University of California, San Diego
-
- Dooley, Mary Anne (författare)
- University of North Carolina
-
- Petri, Michelle (författare)
- Johns Hopkins University School of Medicine
-
- Aranow, Cynthia (författare)
- Feinstein Institutes for Medical Research
-
- Van Vollenhoven, Ronald (författare)
- Academic Medical Center of University of Amsterdam (AMC)
-
- Stoll, Thomas (författare)
- Kantonsspital Schaffhausen
-
- Alarcón, Graciela S. (författare)
- University of Alabama at Birmingham School of Medicine
-
- Lim, S. Sam (författare)
- Emory University
-
- Ruiz-Irastorza, Guillermo (författare)
- Biocruces Bizkaia Health Research Institute
-
- Peschken, Christine A. (författare)
- University of Manitoba
-
- Askanase, Anca D. (författare)
- Columbia University
-
- Kamen, Diane L. (författare)
- Medical University of South Carolina
-
- Inanç, Murat (författare)
- Istanbul University
-
- Ramsey-Goldman, Rosalind (författare)
- Northwestern University Feinberg School of Medicine
-
- Bruce, Ian N. (författare)
- University of Manchester
-
visa färre...
-
(creator_code:org_t)
- 2021-02-08
- 2021
- Engelska 11 s.
-
Ingår i: Rheumatology (United Kingdom). - : Oxford University Press (OUP). - 1462-0324 .- 1462-0332. ; 60:10, s. 4737-4747
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://discovery.uc...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Objectives: Vitamin D (25(OH)D) deficiency and metabolic syndrome (MetS) may both contribute to increased cardiovascular risk in SLE. We aimed to examine the association of demographic factors, SLE phenotype, therapy and vitamin D levels with MetS and insulin resistance. Methods: The Systemic Lupus International Collaborating Clinics (SLICC) enrolled patients recently diagnosed with SLE (<15 months) from 33 centres across 11 countries from 2000. Clinical, laboratory and therapeutic data were collected. Vitamin D level was defined according to tertiles based on distribution across this cohort, which were set at T1 (10-36 nmol/l), T2 (37-60 nmol/l) and T3 (61-174 nmol/l). MetS was defined according to the 2009 consensus statement from the International Diabetes Federation. Insulin resistance was determined using the HOMA-IR model. Linear and logistic regressions were used to assess the association of variables with vitamin D levels. Results: Of the 1847 patients, 1163 (63%) had vitamin D measured and 398 (34.2%) subjects were in the lowest 25(OH)D tertile. MetS was present in 286 of 860 (33%) patients whose status could be determined. Patients with lower 25(OH)D were more likely to have MetS and higher HOMA-IR. The MetS components, hypertension, hypertriglyceridemia and decreased high-density lipoprotein (HDL) were all significantly associated with lower 25(OH)D. Increased average glucocorticoid exposure was associated with higher insulin resistance. Conclusions: MetS and insulin resistance are associated with lower vitamin D in patients with SLE. Further studies could determine whether vitamin D repletion confers better control of these cardiovascular risk factors and improve long-term outcomes in SLE.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- Cardiovascular disease
- Epidemiology
- Systemic lupus erythematosus
- Vitamin D
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Chew, Christine
-
Reynolds, John A ...
-
Lertratanakul, A ...
-
Wu, Peggy
-
Urowitz, Murray
-
Gladman, Dafna D ...
-
visa fler...
-
Fortin, Paul R.
-
Bae, Sang Cheol
-
Gordon, Caroline
-
Clarke, Ann E.
-
Bernatsky, Sasha
-
Hanly, John G.
-
Isenberg, David
-
Rahman, Anisur
-
Sanchez-Guerrero ...
-
Romero-Diaz, Jua ...
-
Merrill, Joan
-
Wallace, Daniel
-
Ginzler, Ellen
-
Khamashta, Munth ...
-
Nived, Ola
-
Jönsen, Andreas
-
Steinsson, Krist ...
-
Manzi, Susan
-
Kalunian, Ken
-
Dooley, Mary Ann ...
-
Petri, Michelle
-
Aranow, Cynthia
-
Van Vollenhoven, ...
-
Stoll, Thomas
-
Alarcón, Graciel ...
-
Lim, S. Sam
-
Ruiz-Irastorza, ...
-
Peschken, Christ ...
-
Askanase, Anca D ...
-
Kamen, Diane L.
-
Inanç, Murat
-
Ramsey-Goldman, ...
-
Bruce, Ian N.
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Endokrinologi oc ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Reumatologi och ...
- Artiklar i publikationen
-
Rheumatology (Un ...
- Av lärosätet
-
Lunds universitet