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Comparative express...
Comparative expression analysis of immune-related markers in surgically resected lung neuroendocrine neoplasms
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- Ferencz, Bence (author)
- National Korányi Institute for Tuberculosis and Pulmonology, Hungary,National Institute of Oncology, Budapest
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- Megyesfalvi, Zsolt (author)
- National Institute of Oncology, Budapest,National Korányi Institute for Tuberculosis and Pulmonology, Hungary,Medical University of Vienna
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- Csende, Kristóf (author)
- National Institute of Oncology, Budapest
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- Fillinger, János (author)
- National Korányi Institute for Tuberculosis and Pulmonology, Hungary
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- Poór, Valentin (author)
- National Institute of Oncology, Budapest
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- Lantos, András (author)
- National Korányi Institute for Tuberculosis and Pulmonology, Hungary
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- Pipek, Orsolya (author)
- Eötvös Loránd University
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- Sólyom-Tisza, Anna (author)
- National Korányi Institute for Tuberculosis and Pulmonology, Hungary
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- Rényi-Vámos, Ferenc (author)
- National Institute of Oncology, Budapest,National Korányi Institute for Tuberculosis and Pulmonology, Hungary
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- Schelch, Karin (author)
- Medical University of Vienna
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- Lang, Christian (author)
- Medical University of Vienna
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- Schwendenwein, Anna (author)
- Medical University of Vienna
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- Boettiger, Kristiina (author)
- Medical University of Vienna
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- László, Viktória (author)
- National Korányi Institute for Tuberculosis and Pulmonology, Hungary,Medical University of Vienna
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- Hoetzenecker, Konrad (author)
- Medical University of Vienna
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- Döme, Balázs (author)
- Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups,Medical University of Vienna,National Korányi Institute for Tuberculosis and Pulmonology, Hungary,National Institute of Oncology, Budapest
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- Berta, Judit (author)
- National Korányi Institute for Tuberculosis and Pulmonology, Hungary
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: Lung Cancer. - 0169-5002. ; 181
- Related links:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background: Although immunotherapy has led to a paradigm shift in the treatment of lung cancer, the therapeutic approaches for lung neuroendocrine neoplasms (LNENs) are still limited. Our aim was to explore the immunological landscape and the expression of immune checkpoint markers in LNENs. Methods: Surgically removed tumor samples of 26 atypical carcinoid (AC), 30 large cell neuroendocrine carcinoma (LCNEC) and 29 small cell lung cancer (SCLC) patients were included. The immune phenotype of each tumor type was assessed by using a panel of 15 immune-related markers. As these markers are potentially expressed by immune cells and/or tumor cells, they might serve as putative targets for immunotherapy. Expression patterns were measured by immunohistochemistry and correlated with clinicopathological parameters and prognosis. Results: Unsupervised hierarchical clustering revealed distinct immunologic profiles across tumor types. Specifically, AC tumors were characterized by high tumor cell CD40 expression and low levels of immune infiltrates whereas SCLC samples had a high CD47 and Inducible T Cell Costimulator (ICOS) expression in tumor cells and immune cells, respectively. High CD70 and CD137 expression by tumor cells as well as elevated expression of CD27, Lymphocyte Activation Gene 3 (LAG3), and CD40 by immune cells were characteristic for LCNEC samples. Overall, SCLC and LCNEC tumors had a more immunogenic phenotype than AC samples. High tumor cell CD47 and CD40 expressions were associated with impaired and improved survival outcomes, respectively. Conclusions: By providing insights into the widely divergent immunologic profiles of LNENs, our results might serve as a basis for the development of novel immunotherapy-related approaches in these devastating malignancies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Immune phenotype
- Immune-related markers
- Immunohistochemistry
- Lung neuroendocrine tumors
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Ferencz, Bence
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Megyesfalvi, Zso ...
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Csende, Kristóf
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Fillinger, János
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Poór, Valentin
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Lantos, András
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Pipek, Orsolya
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Sólyom-Tisza, An ...
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Rényi-Vámos, Fer ...
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Schelch, Karin
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Lang, Christian
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Schwendenwein, A ...
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Boettiger, Krist ...
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László, Viktória
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Hoetzenecker, Ko ...
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Döme, Balázs
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Berta, Judit
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Lung Cancer
- By the university
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Lund University