Search: WFRF:(Robinson Jennifer G) >
Association of low-...
Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks.
- Article/chapterEnglish2014
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:lup.lub.lu.se:5867df04-a8e1-436a-ac9a-3428a708efe4
-
https://lup.lub.lu.se/record/4335257URI
-
https://doi.org/10.1016/j.ajhg.2014.01.009DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:art swepub-publicationtype
-
Subject category:ref swepub-contenttype
Notes
-
Low-frequency coding DNA sequence variants in the proprotein convertase subtilisin/kexin type 9 gene (PCSK9) lower plasma low-density lipoprotein cholesterol (LDL-C), protect against risk of coronary heart disease (CHD), and have prompted the development of a new class of therapeutics. It is uncertain whether the PCSK9 example represents a paradigm or an isolated exception. We used the "Exome Array" to genotype >200,000 low-frequency and rare coding sequence variants across the genome in 56,538 individuals (42,208 European ancestry [EA] and 14,330 African ancestry [AA]) and tested these variants for association with LDL-C, high-density lipoprotein cholesterol (HDL-C), and triglycerides. Although we did not identify new genes associated with LDL-C, we did identify four low-frequency (frequencies between 0.1% and 2%) variants (ANGPTL8 rs145464906 [c.361C>T; p.Gln121(∗)], PAFAH1B2 rs186808413 [c.482C>T; p.Ser161Leu], COL18A1 rs114139997 [c.331G>A; p.Gly111Arg], and PCSK7 rs142953140 [c.1511G>A; p.Arg504His]) with large effects on HDL-C and/or triglycerides. None of these four variants was associated with risk for CHD, suggesting that examples of low-frequency coding variants with robust effects on both lipids and CHD will be limited.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Auer, Paul L
(author)
-
Bis, Joshua C
(author)
-
Voorman, Arend
(author)
-
Morrison, Alanna C
(author)
-
Stitziel, Nathan O
(author)
-
Brody, Jennifer A
(author)
-
Khetarpal, Sumeet A
(author)
-
Crosby, Jacy R
(author)
-
Fornage, Myriam
(author)
-
Isaacs, Aaron
(author)
-
Jakobsdottir, Johanna
(author)
-
Feitosa, Mary F
(author)
-
Davies, Gail
(author)
-
Huffman, Jennifer E
(author)
-
Manichaikul, Ani
(author)
-
Davis, Brian
(author)
-
Lohman, Kurt
(author)
-
Joon, Aron Y
(author)
-
Smith, Albert V
(author)
-
Grove, Megan L
(author)
-
Zanoni, Paolo
(author)
-
Redon, Valeska
(author)
-
Demissie, Serkalem
(author)
-
Lawson, Kim
(author)
-
Peters, Ulrike
(author)
-
Carlson, Christopher
(author)
-
Jackson, Rebecca D
(author)
-
Ryckman, Kelli K
(author)
-
Mackey, Rachel H
(author)
-
Robinson, Jennifer G
(author)
-
Siscovick, David S
(author)
-
Schreiner, Pamela J
(author)
-
Mychaleckyj, Josyf C
(author)
-
Pankow, James S
(author)
-
Hofman, Albert
(author)
-
Uitterlinden, Andre G
(author)
-
Harris, Tamara B
(author)
-
Taylor, Kent D
(author)
-
Stafford, Jeanette M
(author)
-
Reynolds, Lindsay M
(author)
-
Marioni, Riccardo E
(author)
-
Dehghan, Abbas
(author)
-
Franco, Oscar H
(author)
-
Patel, Aniruddh P
(author)
-
Lu, Yingchang
(author)
-
Hindy, GeorgeLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups(Swepub:lu)med-ghu
(author)
-
Gottesman, Omri
(author)
-
Bottinger, Erwin P
(author)
-
Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome
(author)
-
Orho-Melander, MarjuLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups(Swepub:lu)endo-mor
(author)
-
Loos, Ruth J F
(author)
-
Duga, Stefano
(author)
-
Merlini, Piera Angelica
(author)
-
Farrall, Martin
(author)
-
Goel, Anuj
(author)
-
Asselta, Rosanna
(author)
-
Girelli, Domenico
(author)
-
Martinelli, Nicola
(author)
-
Shah, Svati H
(author)
-
Kraus, William E
(author)
-
Li, Mingyao
(author)
-
Rader, Daniel J
(author)
-
Reilly, Muredach P
(author)
-
McPherson, Ruth
(author)
-
Watkins, Hugh
(author)
-
Ardissino, Diego
(author)
-
Zhang, Qunyuan
(author)
-
Wang, Judy
(author)
-
Tsai, Michael Y
(author)
-
Taylor, Herman A
(author)
-
Correa, Adolfo
(author)
-
Griswold, Michael E
(author)
-
Lange, Leslie A
(author)
-
Starr, John M
(author)
-
Rudan, Igor
(author)
-
Eiriksdottir, Gudny
(author)
-
Launer, Lenore J
(author)
-
Ordovas, Jose M
(author)
-
Levy, Daniel
(author)
-
Chen, Y-D Ida
(author)
-
Reiner, Alexander P
(author)
-
Hayward, Caroline
(author)
-
Polasek, Ozren
(author)
-
Deary, Ian J
(author)
-
Borecki, Ingrid B
(author)
-
Liu, Yongmei
(author)
-
Gudnason, Vilmundur
(author)
-
Wilson, James G
(author)
-
van Duijn, Cornelia M
(author)
-
Kooperberg, Charles
(author)
-
Rich, Stephen S
(author)
-
Psaty, Bruce M
(author)
-
Rotter, Jerome I
(author)
-
O'Donnell, Christopher J
(author)
-
Rice, Kenneth
(author)
-
Boerwinkle, Eric
(author)
-
Kathiresan, Sekar
(author)
-
Cupples, L Adrienne
(author)
-
Diabetes - kardiovaskulär sjukdomForskargrupper vid Lunds universitet
(creator_code:org_t)
Related titles
-
In:American Journal of Human Genetics: Elsevier BV94:2, s. 223-2320002-9297
Internet link
Find in a library
To the university's database
- By the author/editor
-
Peloso, Gina M
-
Auer, Paul L
-
Bis, Joshua C
-
Voorman, Arend
-
Morrison, Alanna ...
-
Stitziel, Nathan ...
-
show more...
-
Brody, Jennifer ...
-
Khetarpal, Sumee ...
-
Crosby, Jacy R
-
Fornage, Myriam
-
Isaacs, Aaron
-
Jakobsdottir, Jo ...
-
Feitosa, Mary F
-
Davies, Gail
-
Huffman, Jennife ...
-
Manichaikul, Ani
-
Davis, Brian
-
Lohman, Kurt
-
Joon, Aron Y
-
Smith, Albert V
-
Grove, Megan L
-
Zanoni, Paolo
-
Redon, Valeska
-
Demissie, Serkal ...
-
Lawson, Kim
-
Peters, Ulrike
-
Carlson, Christo ...
-
Jackson, Rebecca ...
-
Ryckman, Kelli K
-
Mackey, Rachel H
-
Robinson, Jennif ...
-
Siscovick, David ...
-
Schreiner, Pamel ...
-
Mychaleckyj, Jos ...
-
Pankow, James S
-
Hofman, Albert
-
Uitterlinden, An ...
-
Harris, Tamara B
-
Taylor, Kent D
-
Stafford, Jeanet ...
-
Reynolds, Lindsa ...
-
Marioni, Riccard ...
-
Dehghan, Abbas
-
Franco, Oscar H
-
Patel, Aniruddh ...
-
Lu, Yingchang
-
Hindy, George
-
Gottesman, Omri
-
Bottinger, Erwin ...
-
Melander, Olle
-
Orho-Melander, M ...
-
Loos, Ruth J F
-
Duga, Stefano
-
Merlini, Piera A ...
-
Farrall, Martin
-
Goel, Anuj
-
Asselta, Rosanna
-
Girelli, Domenic ...
-
Martinelli, Nico ...
-
Shah, Svati H
-
Kraus, William E
-
Li, Mingyao
-
Rader, Daniel J
-
Reilly, Muredach ...
-
McPherson, Ruth
-
Watkins, Hugh
-
Ardissino, Diego
-
Zhang, Qunyuan
-
Wang, Judy
-
Tsai, Michael Y
-
Taylor, Herman A
-
Correa, Adolfo
-
Griswold, Michae ...
-
Lange, Leslie A
-
Starr, John M
-
Rudan, Igor
-
Eiriksdottir, Gu ...
-
Launer, Lenore J
-
Ordovas, Jose M
-
Levy, Daniel
-
Chen, Y-D Ida
-
Reiner, Alexande ...
-
Hayward, Carolin ...
-
Polasek, Ozren
-
Deary, Ian J
-
Borecki, Ingrid ...
-
Liu, Yongmei
-
Gudnason, Vilmun ...
-
Wilson, James G
-
van Duijn, Corne ...
-
Kooperberg, Char ...
-
Rich, Stephen S
-
Psaty, Bruce M
-
Rotter, Jerome I
-
O'Donnell, Chris ...
-
Rice, Kenneth
-
Boerwinkle, Eric
-
Kathiresan, Seka ...
-
Cupples, L Adrie ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Medical Genetics
- Articles in the publication
-
American Journal ...
- By the university
-
Lund University