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Sökning: WFRF:(Jørgensen J. K.) > (2005-2009) > Detection of chromo...

  • Sperling, L. (författare)

Detection of chromosomal abnormalities, congenital abnormalities and transfusion syndrome in twins

  • Artikel/kapitelEngelska2007

Förlag, utgivningsår, omfång ...

  • 2007
  • Wiley,2007

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:593d3fb6-8799-4479-becf-3941f0e9e11d
  • https://lup.lub.lu.se/record/651256URI
  • https://doi.org/10.1002/uog.3918DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Objective To evaluate the outcome of screening for structural malformations in twins and the outcome of screening for twin-twin transfusion syndrome (TTTS) among monochorionic twins through a number of ultrasound scans from 12 weeks' gestation. Methods Enrolled into this prospective multicenter observational study were women with twin pregnancies diagnosed before 14 + 6 gestational weeks. The monochorionic pregnancies were scanned every second week until 23 weeks in order to rule out early TTTS. All pregnancies had an anomaly scan in week 19 and fetal echocardiography in week 21 that was performed by specialists in fetal echocardiography. Zygosity was determined by DNA analysis in all twin pairs with the same sex. Results Among the 495 pregnancies the prenatal detection rate for severe structural abnormalities including chromosomal aneuploidies was 83% by the combination of a first-trimester nuchal translucency scan and the anomaly scan in week 19. The incidence of severe structural abnormalities was 2.6% and two-thirds of these anomalies were cardiac. There was no significant difference between the incidence in monozygotic and dizygotic twins, nor between twins conceived naturally or those conceived by assisted reproduction. The incidence of TTTS was 23% from 12 weeks until delivery, and all those monochorionic twin pregnancies that miscarried had signs of TTTS. Conclusion Twin pregnancies have an increased risk of congenital malformations and one out of four monochorionic pregnancies develops TTTS. Ultrasound screening to assess chorionicity and follow-up of monochorionic pregnancies to detect signs of TTTS, as well as malformation screening, are therefore essential in the antenatal care of twin pregnancies. Copyright (c) 2007 IS UOG. Published by John Wiley & Sons, Ltd.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Kill, C. (författare)
  • Larsen, L. U. (författare)
  • Brocks, V. (författare)
  • Wojdemann, K. R. (författare)
  • Qvist, I. (författare)
  • Schwartz, M. (författare)
  • Jörgensen, ConnieLund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)extLU-174 (författare)
  • Espersen, G. (författare)
  • Skajaa, K. (författare)
  • Bang, J. (författare)
  • Tabor, A. (författare)
  • Obstetrik och gynekologi, LundSektion V (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Ultrasound in Obstetrics & Gynecology: Wiley29:5, s. 517-5261469-07050960-7692

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