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Minimal residual di...
Minimal residual disease assessed with deep sequencing of NPM1 mutations predicts relapse after allogeneic stem cell transplant in AML
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- Malmberg, Erik (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för biomedicin,Institute of Biomedicine
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- Alm, Sofie J., 1988 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för biomedicin,Institute of Biomedicine
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- Nicklasson, Malin (author)
- Sahlgrenska University Hospital
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- Lazarevic, Vladimir (author)
- Skåne University Hospital
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- Ståhlman, Sara (author)
- Sahlgrenska University Hospital
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- Samuelsson, Tore, 1951 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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- Lenhoff, Stig (author)
- Skåne University Hospital
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- Asp, Julia, 1973 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,Institutionen för biomedicin,Institute of Biomedicine
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- Ehinger, Mats (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Palmqvist, Lars, 1965 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,Institutionen för biomedicin,Institute of Biomedicine
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- Brune, Mats, 1950 (author)
- Sahlgrenska University Hospital
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- Fogelstrand, Linda, 1974 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,Institutionen för biomedicin,Institute of Biomedicine
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(creator_code:org_t)
- 2018-08-02
- 2019
- English.
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In: Leukemia and Lymphoma. - : Informa UK Limited. - 1042-8194 .- 1029-2403. ; 60:2, s. 409-417
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Abstract
Subject headings
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- Mutations in NPM1 can be used for minimal residual disease (MRD) analysis in acute myeloid leukemia (AML). We here applied a newly introduced method, deep sequencing, allowing for simultaneous analysis of all recurrent NPM1 insertions and thus constituting an attractive alternative to multiple PCRs for the clinical laboratory. We retrospectively used deep sequencing for measurement of MRD pre- and post-allogeneic hematopoietic stem cell transplantation (alloHCT). For 29 patients in morphological remission at the time of alloHCT, the effect of deep sequencing MRD on outcome was assessed. MRD positivity was defined as variant allele frequency ≥0.02%. Post-transplant MRD status was significantly and independently associated with clinical outcome; 3-year relapse-free survival 20% vs 85% (p <.001), HR 45 (95% CI 2–1260), and overall survival 20% vs 89% (p <.001), HR 49 (95% CI 2–1253). Thus, the new methodology deep sequencing is an applicable and predictive tool for MRD assessment in AML.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology (hsv//eng)
Keyword
- Acute myeloid leukemia
- massively parallel sequencing
- minimal residual disease
Publication and Content Type
- art (subject category)
- ref (subject category)
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Malmberg, Erik
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Alm, Sofie J., 1 ...
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Nicklasson, Mali ...
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Lazarevic, Vladi ...
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Ståhlman, Sara
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Samuelsson, Tore ...
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Lenhoff, Stig
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Asp, Julia, 1973
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Ehinger, Mats
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Palmqvist, Lars, ...
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Brune, Mats, 195 ...
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Fogelstrand, Lin ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Clinical Laborat ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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Leukemia and Lym ...
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Lund University
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University of Gothenburg