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Thrombocytopenia an...
Thrombocytopenia and platelet transfusions in ICU patients : an international inception cohort study (PLOT-ICU)
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- Anthon, Carl Thomas (author)
- Copenhagen University Hospital
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Pène, Frédéric (author)
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Perner, Anders (author)
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- Barratt-Due, Andreas (author)
- Oslo university hospital
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- Chawla, Sanjay (author)
- Memorial Sloan-Kettering Cancer Center
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- Kander, Thomas (author)
- Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk forskning inom anestesi och intensivvårdsmedicin,Forskargrupper vid Lunds universitet,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Research in Anaesthesia and Intensive Care Medicine,Lund University Research Groups,Skåne University Hospital
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Hästbacka, Johanna (author)
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- Andreasen, Jo Bønding (author)
- Aalborg University Hospital
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Péju, Edwige (author)
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- Nielsen, Lene Bjerregaard (author)
- Odense University Hospital
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- Hvas, Christine Lodberg (author)
- Aarhus University Hospital
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Dufranc, Etienne (author)
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Canet, Emmanuel (author)
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Lundqvist, Linda (author)
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Wright, Christopher John (author)
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- Voiriot, Guillaume (author)
- Assistance Publique des Hôpitaux de Paris
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- Clausen, Niels Erikstrup (author)
- Bispebjerg Hospital
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Lorentzen, Kristian (author)
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- Kvåle, Reidar (author)
- Haukeland University Hospital
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Hildebrandt, Thomas (author)
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- Holten, Aleksander Rygh (author)
- Oslo university hospital
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- Strand, Kristian (author)
- Stavanger University Hospital
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- Tzalavras, Asterios (author)
- University Hospital Essen
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Bestle, Morten Heiberg (author)
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Klepstad, Pål (author)
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- Fernandez, Sara (author)
- University of Barcelona
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Vimpere, Damien (author)
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- Paulino, Carolina (author)
- NOVA University Lisbon
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Costa, Carolina (author)
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Bådstøløkken, Per Martin (author)
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- Miranda, Teresa (author)
- Centro Hospitalar de Lisboa Ocidental (CHLO)
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- Russell, Lene (author)
- Copenhagen University Hospital
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(creator_code:org_t)
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- 2023
- 2023
- English.
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In: Intensive Care Medicine. - 0342-4642. ; 49:11, s. 1327-1338
- Related links:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- PURPOSE: Thrombocytopenia (platelet count < 150 × 10 9/L) is common in intensive care unit (ICU) patients and is likely associated with worse outcomes. In this study we present international contemporary data on thrombocytopenia in ICU patients. METHODS: We conducted a prospective cohort study in adult ICU patients in 52 ICUs across 10 countries. We assessed frequencies of thrombocytopenia, use of platelet transfusions and clinical outcomes including mortality. We evaluated pre-selected potential risk factors for the development of thrombocytopenia during ICU stay and associations between thrombocytopenia at ICU admission and 90-day mortality using pre-specified logistic regression analyses.RESULTS: We analysed 1166 ICU patients; the median age was 63 years and 39.5% were female. Overall, 43.2% (95% confidence interval (CI) 40.4-46.1) had thrombocytopenia; 23.4% (20-26) had thrombocytopenia at ICU admission, and 19.8% (17.6-22.2) developed thrombocytopenia during their ICU stay. Absence of acquired immune deficiency syndrome (AIDS), non-cancer-related immune deficiency, liver failure, male sex, septic shock, and bleeding at ICU admission were associated with the development of thrombocytopenia during ICU stay. Among patients with thrombocytopenia, 22.6% received platelet transfusion(s), and 64.3% of in-ICU transfusions were prophylactic. Patients with thrombocytopenia had higher occurrences of bleeding and death, fewer days alive without the use of life-support, and fewer days alive and out of hospital. Thrombocytopenia at ICU admission was associated with 90-day mortality (adjusted odds ratio 1.7; 95% CI 1.19-2.42).CONCLUSION: Thrombocytopenia occurred in 43% of critically ill patients and was associated with worse outcomes including increased mortality. Platelet transfusions were given to 23% of patients with thrombocytopenia and most were prophylactic.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
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- By the author/editor
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Anthon, Carl Tho ...
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Pène, Frédéric
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Perner, Anders
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Barratt-Due, And ...
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Chawla, Sanjay
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Kander, Thomas
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show more...
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Hästbacka, Johan ...
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Andreasen, Jo Bø ...
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Péju, Edwige
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Nielsen, Lene Bj ...
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Hvas, Christine ...
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Dufranc, Etienne
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Canet, Emmanuel
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Lundqvist, Linda
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Wright, Christop ...
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Voiriot, Guillau ...
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Clausen, Niels E ...
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Lorentzen, Krist ...
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Kvåle, Reidar
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Hildebrandt, Tho ...
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Holten, Aleksand ...
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Strand, Kristian
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Tzalavras, Aster ...
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Bestle, Morten H ...
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Klepstad, Pål
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Fernandez, Sara
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Vimpere, Damien
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Paulino, Carolin ...
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Costa, Carolina
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Bådstøløkken, Pe ...
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Miranda, Teresa
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Russell, Lene
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Anesthesiology a ...
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Intensive Care M ...
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Lund University