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Platelet transfusio...
Platelet transfusions in adult thrombocytopenic ICU patients : Protocol for a sub-study of the PLOT-ICU cohort
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- Anthon, Carl Thomas (author)
- Copenhagen University Hospital
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- Pène, Frédéric (author)
- Université Paris Cité
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- Perner, Anders (author)
- Copenhagen University Hospital,University of Copenhagen
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- Azoulay, Elie (author)
- Université Paris Cité,Assistance Publique des Hôpitaux de Paris
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- Puxty, Kathryn (author)
- Glasgow Royal Infirmary
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- Van De Louw, Andry (author)
- Pennsylvania State University College of Medicine
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- Chawla, Sanjay (author)
- Weill Cornell Medical College,Memorial Sloan-Kettering Cancer Center
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- Castro, Pedro (author)
- University of Barcelona
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- Povoa, Pedro (author)
- Centro Hospitalar de Lisboa Ocidental (CHLO)
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- Coelho, Luis (author)
- Centro Hospitalar de Lisboa Ocidental (CHLO),NOVA University Lisbon,Odense University Hospital
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- Metaxa, Victoria (author)
- King's College Hospital
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- Kochanek, Matthias (author)
- University Hospital of Cologne
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- Liebregts, Tobias (author)
- University Hospital Essen
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- Kander, Thomas (author)
- Lund University,Lunds universitet,Klinisk forskning inom anestesi och intensivvårdsmedicin,Forskargrupper vid Lunds universitet,Clinical Research in Anaesthesia and Intensive Care Medicine,Lund University Research Groups,Skåne University Hospital
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- Sivula, Mirka (author)
- University of Helsinki,Hospital for Children and Adolescents, Helsinki
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- Møller, Morten Hylander (author)
- University of Copenhagen,Copenhagen University Hospital
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- Russell, Lene (author)
- Copenhagen University Hospital,University of Copenhagen,Université Paris Cité
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(creator_code:org_t)
- English.
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In: Acta Anaesthesiologica Scandinavica. - 0001-5172.
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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Abstract
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- INTRODUCTION: Platelet transfusions are frequently used in intensive care unit (ICU) patients, but contemporary epidemiological data are sparse. We aim to present contemporary international data on the use of platelet transfusions in adult ICU patients with thrombocytopenia.METHODS: This is a protocol and statistical analysis plan for a post hoc sub-study of 504 thrombocytopenic patients from the 'Thrombocytopenia and platelet transfusions in ICU patients: an international inception cohort study (PLOT-ICU)'. The primary outcome will be the number of patients receiving platelet transfusion in the ICU reported according to the type of product received (apheresis-derived versus pooled whole-blood-derived transfusions). Secondary platelet transfusion outcomes will include platelet transfusion volumes; timing of platelet transfusion; approach to platelet transfusion dosing (fixed dosing versus weight-based dosing) and platelet count increments for prophylactic transfusions. Secondary clinical outcomes will include the number of patients receiving red blood cell- and plasma transfusions during ICU stay; the number of patients who bled in the ICU, the number of patients who had a new thrombosis in the ICU, and the number of patients who died. The duration of follow-up was 90 days. Baseline characteristics and secondary clinical outcomes will be stratified according to platelet transfusion status in the ICU and severity of thrombocytopenia. Data will be presented descriptively.CONCLUSIONS: The outlined study will provide detailed epidemiological data on the use of platelet transfusions in adult ICU patients with thrombocytopenia using data from the large international PLOT-ICU cohort study. The findings will inform the design of future randomised trials evaluating platelet transfusions in ICU patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Anthon, Carl Tho ...
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Pène, Frédéric
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Perner, Anders
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Azoulay, Elie
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Puxty, Kathryn
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Van De Louw, And ...
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show more...
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Chawla, Sanjay
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Castro, Pedro
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Povoa, Pedro
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Coelho, Luis
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Metaxa, Victoria
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Kochanek, Matthi ...
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Liebregts, Tobia ...
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Kander, Thomas
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Sivula, Mirka
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Møller, Morten H ...
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Russell, Lene
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Anesthesiology a ...
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Acta Anaesthesio ...
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Lund University