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Blood pressure and LDL-cholesterol targets for prevention of recurrent strokes and cognitive decline in the hypertensive patient: design of the European Society of Hypertension-Chinese Hypertension League Stroke in Hypertension Optimal Treatment randomized trial.

Zanchetti, Alberto (author)
Liu, Lisheng (author)
Mancia, Giuseppe (author)
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Parati, Gianfranco (author)
Grassi, Guido (author)
Stramba-Badiale, Marco (author)
Silani, Vincenzo (author)
Bilo, Grzegorz (author)
Corrao, Giovanni (author)
Zambon, Antonella (author)
Scotti, Lorenza (author)
Zhang, Xinhua (author)
Wang, HayYan (author)
Zhang, Yuqing (author)
Zhang, Xuezhong (author)
Guan, Ting Rui (author)
Berge, Eivind (author)
Redon, Josep (author)
Narkiewicz, Krzysztof (author)
Dominiczak, Anna (author)
Nilsson, Peter (author)
Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
Viigimaa, Margus (author)
Laurent, Stéphane (author)
Agabiti-Rosei, Enrico (author)
Wu, Zhaosu (author)
Zhu, Dingliang (author)
Rodicio, José Luis (author)
Ruilope, Luis Miguel (author)
Martell-Claros, Nieves (author)
Pinto, Fernando (author)
Schmieder, Roland E (author)
Burnier, Michel (author)
Banach, Maciej (author)
Cifkova, Renata (author)
Farsang, Csaba (author)
Konradi, Alexandra (author)
Lazareva, Irina (author)
Sirenko, Yuriy (author)
Dorobantu, Maria (author)
Postadzhiyan, Arman (author)
Accetto, Rok (author)
Jelakovic, Bojan (author)
Lovic, Dragan (author)
Manolis, Athanasios J (author)
Stylianou, Philippos (author)
Erdine, Serap (author)
Dicker, Dror (author)
Wei, Gangzhi (author)
Xu, Chengbin (author)
Xie, Hengge (author)
Coca, Antonio (author)
O'Brien, John (author)
Ford, Gary (author)
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 (creator_code:org_t)
2014
2014
English.
In: Journal of Hypertension. - 1473-5598. ; 32:9, s. 1888-1897
Related links:
http://www.ncbi.nlm....
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http://dx.doi.org/10...
https://lup.lub.lu.s...
https://doi.org/10.1...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • The SBP values to be achieved by antihypertensive therapy in order to maximize reduction of cardiovascular outcomes are unknown; neither is it clear whether in patients with a previous cardiovascular event, the optimal values are lower than in the low-to-moderate risk hypertensive patients, or a more cautious blood pressure (BP) reduction should be obtained. Because of the uncertainty whether 'the lower the better' or the 'J-curve' hypothesis is correct, the European Society of Hypertension and the Chinese Hypertension League have promoted a randomized trial comparing antihypertensive treatment strategies aiming at three different SBP targets in hypertensive patients with a recent stroke or transient ischaemic attack. As the optimal level of low-density lipoprotein cholesterol (LDL-C) level is also unknown in these patients, LDL-C-lowering has been included in the design.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Publication and Content Type

art (subject category)
ref (subject category)

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