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Dietary metabolite ...
Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk : An IMI DIRECT study
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- Eriksen, Rebeca (författare)
- Imperial College London,Imperial Coll London, Fac Med, Dept Metab Digest & Reprod, Sect Nutr Res,Div Digest Dis, London W12 0NN, England.
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- Perez, Isabel Garcia (författare)
- Imperial College London
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- Posma, Joram M. (författare)
- Imperial College London,Health Data Research UK
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- Haid, Mark (författare)
- Helmholtz Zentrum München
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- Sharma, Sapna (författare)
- German Center for Diabetes Research,Helmholtz Zentrum München
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- Prehn, Cornelia (författare)
- Helmholtz Zentrum München
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- Thomas, Louise E. (författare)
- University of Westminster
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- Koivula, Robert W. (författare)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Skåne University Hospital,University of Oxford
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- Bizzotto, Roberto (författare)
- Institute of Neuroscience, Università di Padova
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- Mari, Andrea (författare)
- Institute of Neuroscience, Università di Padova
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- Giordano, Giuseppe N. (författare)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Skåne University Hospital
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- Pavo, Imre (författare)
- Eli Lilly Regional Operations G.m.b.H.
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- Schwenk, Jochen M. (författare)
- KTH,KTH Royal Institute of Technology,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab
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- De Masi, Federico (författare)
- University of Copenhagen,Technical University of Denmark
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- Tsirigos, Konstantinos D. (författare)
- University of Copenhagen,Technical University of Denmark
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- Brunak, Søren (författare)
- Technical University of Denmark,University of Copenhagen
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- Viñuela, Ana (författare)
- University of Geneva
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- Mahajan, Anubha (författare)
- Wellcome Trust Centre for Human Genetics,University of Oxford
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- McDonald, Timothy J. (författare)
- University of Exeter
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- Kokkola, Tarja (författare)
- University of Eastern Finland,Kuopio University Hospital
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- Rutter, Femke (författare)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Teare, Harriet (författare)
- University of Oxford,Wellcome Trust Centre for Human Genetics
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- Hansen, Tue H. (författare)
- University of Copenhagen
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- Fernandez, Juan (författare)
- University of Oxford,Wellcome Trust Centre for Human Genetics
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- Jones, Angus (författare)
- University of Exeter
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- Jennison, Chris (författare)
- University of Bath
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- Walker, Mark (författare)
- University of Newcastle upon Tyne
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- McCarthy, Mark I. (författare)
- Wellcome Trust Centre for Human Genetics,University of Oxford
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- Pedersen, Oluf (författare)
- University of Copenhagen
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- Ruetten, Hartmut (författare)
- Sanofi-Aventis Deutschland GmbH
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- Forgie, Ian (författare)
- Ninewells Hospital and Medical School,University of Dundee
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- Bell, Jimmy D. (författare)
- University of Westminster
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- Pearson, Ewan R. (författare)
- University of Dundee
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- Franks, Paul W. (författare)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Skåne University Hospital
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- Adamski, Jerzy (författare)
- National University of Singapore,Technical University of Munich,Helmholtz Zentrum München
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- Holmes, Elaine (författare)
- Imperial College London
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- Frost, Gary (författare)
- Churchill Hospital,Imperial College London,Imperial Coll London, Fac Med, Dept Metab Digest & Reprod, Sect Nutr Res,Div Digest Dis, London W12 0NN, England.;Churchill Hosp, NIHR Oxford Biomed Res Ctr, Oxford, England.
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Imperial College London Imperial Coll London, Fac Med, Dept Metab Digest & Reprod, Sect Nutr Res,Div Digest Dis, London W12 0NN, England (creator_code:org_t)
- Elsevier BV, 2020
- 2020
- Engelska.
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Ingår i: EBioMedicine. - : Elsevier BV. - 2352-3964. ; 58
- Relaterad länk:
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http://dx.doi.org/10... (free)
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http://www.thelancet...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background: Dietary advice remains the cornerstone of prevention and management of type 2 diabetes (T2D). However, understanding the efficacy of dietary interventions is confounded by the challenges inherent in assessing free living diet. Here we profiled dietary metabolites to investigate glycaemic deterioration and cardiometabolic risk in people at risk of or living with T2D. Methods: We analysed data from plasma collected at baseline and 18-month follow-up in individuals from the Innovative Medicines Initiative (IMI) Diabetes Research on Patient Stratification (DIRECT) cohort 1 n = 403 individuals with normal or impaired glucose regulation (prediabetic) and cohort 2 n = 458 individuals with new onset of T2D. A dietary metabolite profile model (Tpred) was constructed using multivariable regression of 113 plasma metabolites obtained from targeted metabolomics assays. The continuous Tpred score was used to explore the relationships between diet, glycaemic deterioration and cardio-metabolic risk via multiple linear regression models. Findings: A higher Tpred score was associated with healthier diets high in wholegrain (β=3.36 g, 95% CI 0.31, 6.40 and β=2.82 g, 95% CI 0.06, 5.57) and lower energy intake (β=-75.53 kcal, 95% CI -144.71, -2.35 and β=-122.51 kcal, 95% CI -186.56, -38.46), and saturated fat (β=-0.92 g, 95% CI -1.56, -0.28 and β=–0.98 g, 95% CI -1.53, -0.42 g), respectively for cohort 1 and 2. In both cohorts a higher Tpred score was also associated with lower total body adiposity and favourable lipid profiles HDL-cholesterol (β=0.07 mmol/L, 95% CI 0.03, 0.1), (β=0.08 mmol/L, 95% CI 0.04, 0.1), and triglycerides (β=-0.1 mmol/L, 95% CI -0.2, -0.03), (β=-0.2 mmol/L, 95% CI -0.3, -0.09), respectively for cohort 1 and 2. In cohort 2, the Tpred score was negatively associated with liver fat (β=-0.74%, 95% CI -0.67, -0.81), and lower fasting concentrations of HbA1c (β=-0.9 mmol/mol, 95% CI -1.5, -0.1), glucose (β=-0.2 mmol/L, 95% CI -0.4, -0.05) and insulin (β=-11.0 pmol/mol, 95% CI -19.5, -2.6). Longitudinal analysis showed at 18-month follow up a higher Tpred score was also associated lower total body adiposity in both cohorts and lower fasting glucose (β=-0.2 mmol/L, 95% CI -0.3, -0.01) and insulin (β=-9.2 pmol/mol, 95% CI -17.9, -0.4) concentrations in cohort 2. Interpretation: Plasma dietary metabolite profiling provides objective measures of diet intake, showing a relationship to glycaemic deterioration and cardiometabolic health. Funding: This work was supported by the Innovative Medicines Initiative Joint Undertaking under grant agreement no. 115,317 (DIRECT), resources of which are composed of financial contribution from the European Union's Seventh Framework Programme (FP7/2007–2013) and EFPIA companies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Cardiometabolic health
- Dietary patterns
- Metabolic profiling
- Type 2 diabetes
- Metabolic profiling
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Till lärosätets databas
- Av författaren/redakt...
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Eriksen, Rebeca
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Perez, Isabel Ga ...
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Posma, Joram M.
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Haid, Mark
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Sharma, Sapna
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Prehn, Cornelia
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visa fler...
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Thomas, Louise E ...
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Koivula, Robert ...
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Bizzotto, Robert ...
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Mari, Andrea
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Giordano, Giusep ...
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Pavo, Imre
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Schwenk, Jochen ...
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De Masi, Federic ...
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Tsirigos, Konsta ...
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Brunak, Søren
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Viñuela, Ana
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Mahajan, Anubha
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McDonald, Timoth ...
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Kokkola, Tarja
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Rutter, Femke
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Teare, Harriet
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Hansen, Tue H.
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Fernandez, Juan
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Jones, Angus
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Jennison, Chris
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Walker, Mark
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McCarthy, Mark I ...
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Pedersen, Oluf
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Ruetten, Hartmut
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Forgie, Ian
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Bell, Jimmy D.
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Pearson, Ewan R.
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Franks, Paul W.
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Adamski, Jerzy
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Holmes, Elaine
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Frost, Gary
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Näringslära
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
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EBioMedicine
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Lunds universitet
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