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  • Hall, JulietteUniversity of Calgary (author)

Detection of G Protein-Coupled Receptor Autoantibodies in Postural Orthostatic Tachycardia Syndrome Using Standard Methodology

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022
  • 10 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:5d1c8842-2569-4293-9592-b60821be1e23
  • https://lup.lub.lu.se/record/5d1c8842-2569-4293-9592-b60821be1e23URI
  • https://doi.org/10.1161/CIRCULATIONAHA.122.059971DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:150494093URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • BACKGROUND: Postural orthostatic tachycardia syndrome (POTS) is a disorder of orthostatic intolerance that primarily affects women of childbearing age. The underlying pathophysiology of POTS is not fully understood, but it has been suggested that autoimmunity may play a role. The aim of this study was to compare concentrations of autoantibodies to cardiovascular G protein-coupled receptors between patients with POTS and healthy controls.METHODS: Sera were collected from 116 patients with POTS (91% female; mean age, 29 years) and 81 healthy controls (84% female; mean age, 27 years) from Calgary, Canada, and Malmö, Sweden. Samples were evaluated for autoantibodies to 11 receptors (adrenergic, muscarinic, angiotensin II, and endothelin) using a commercially available enzyme-linked immunosorbent assay.RESULTS: Autoantibody concentrations against all of the receptors tested were not significantly different between controls and patients with POTS. The majority of patients with POTS (98.3%) and all controls (100%) had α1 adrenergic receptor autoantibody concentrations above the seropositive threshold provided by the manufacturer (7 units/mL). The proportion of patients with POTS versus healthy controls who fell above the diagnostic thresholds was not different for any tested autoantibodies. Receiver operating characteristic curves showed a poor ability to discriminate between patients with POTS and controls.CONCLUSION: Patients with POTS and healthy controls do not differ in their enzyme-linked immunosorbent assay-derived autoantibody concentrations to cardiovascular G protein-coupled receptors. These findings suggest that these tests are not useful for establishing the role of autoimmunity in POTS.

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  • Bourne, Kate MUniversity of Calgary (author)
  • Vernino, StevenUniversity of Texas Southwestern Medical Center (author)
  • Hamrefors, ViktorLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-vho (author)
  • Kharraziha, IsabellaLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)is0770kh (author)
  • Nilsson, JanLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine(Swepub:lu)med-jn6 (author)
  • Sheldon, Robert SUniversity of Calgary (author)
  • Fedorowski, ArturKarolinska Institutet,Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Karolinska University Hospital(Swepub:lu)med-afr (author)
  • Raj, Satish RUniversity of Calgary,Vanderbilt University Medical Center (author)
  • University of CalgaryUniversity of Texas Southwestern Medical Center (creator_code:org_t)

Related titles

  • In:Circulation146:8, s. 613-6221524-4539

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