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  • Rafaeva, MariaUniversity of Copenhagen (author)

Modeling Metastatic Colonization in a Decellularized Organ Scaffold-Based Perfusion Bioreactor

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2021-11-17
  • Wiley,2022

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:5d4d2e0c-3ce4-4b87-a754-71eb50c1a1c1
  • https://lup.lub.lu.se/record/5d4d2e0c-3ce4-4b87-a754-71eb50c1a1c1URI
  • https://doi.org/10.1002/adhm.202100684DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Metastatic cancer spread is responsible for most cancer-related deaths. To colonize a new organ, invading cells adapt to, and remodel, the local extracellular matrix (ECM), a network of proteins and proteoglycans underpinning all tissues, and a critical regulator of homeostasis and disease. However, there is a major lack in tools to study cancer cell behavior within native 3D ECM. Here, an in-house designed bioreactor, where mouse organ ECM scaffolds are perfused and populated with cells that are challenged to colonize it, is presented. Using a specialized bioreactor chamber, it is possible to monitor cell behavior microscopically (e.g., proliferation, migration) within the organ scaffold. Cancer cells in this system recapitulate cell signaling observed in vivo and remodel complex native ECM. Moreover, the bioreactors are compatible with co-culturing cell types of different genetic origin comprising the normal and tumor microenvironment. This degree of experimental flexibility in an organ-specific and 3D context, opens new possibilities to study cell–cell and cell–ECM interplay and to model diseases in a controllable organ-specific system ex vivo.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Horton, Edward R.University of Copenhagen (author)
  • Jensen, Adina R.D.University of Copenhagen (author)
  • Madsen, Chris D.Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Cancer and matrix remodelling,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)ch3375ma (author)
  • Reuten, RaphaelUniversity of Copenhagen (author)
  • Willacy, OliverUniversity of Copenhagen (author)
  • Brøchner, Christian B.Copenhagen University Hospital (author)
  • Jensen, Thomas H.Copenhagen University Hospital (author)
  • Zornhagen, Kamilla WestarpUniversity of Copenhagen (author)
  • Crespo, MarinaUniversity of Copenhagen (author)
  • Grønseth, Dina S.University of Copenhagen (author)
  • Nielsen, Sebastian R.University of Copenhagen (author)
  • Idorn, ManjaHerlev Hospital (author)
  • Straten, Per thorHerlev Hospital (author)
  • Rohrberg, KristofferCopenhagen University Hospital (author)
  • Spanggaard, IbenCopenhagen University Hospital (author)
  • Højgaard, MartinCopenhagen University Hospital (author)
  • Lassen, UlrikCopenhagen University Hospital (author)
  • Erler, Janine T.University of Copenhagen (author)
  • Mayorca-Guiliani, Alejandro E.University of Copenhagen (author)
  • University of CopenhagenAvdelningen för translationell cancerforskning (creator_code:org_t)

Related titles

  • In:Advanced healthcare materials: Wiley11:12192-26402192-2659

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