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Impact of prior the...
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Mateos, María-VictoriaUniversity Hospital of Salamanca
(author)
Impact of prior therapy on the efficacy and safety of oral ixazomib-lenalidomide-dexamethasone vs. placebo-lenalidomide-dexamethasone in patients with relapsed/refractory multiple myeloma in TOURMALINE-MM1
- Article/chapterEnglish2017
Publisher, publication year, extent ...
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2017-07-27
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Ferrata Storti Foundation (Haematologica),2017
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9 s.
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:5d8bf9fc-671d-4250-a550-09d655f2be1d
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https://lup.lub.lu.se/record/5d8bf9fc-671d-4250-a550-09d655f2be1dURI
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https://doi.org/10.3324/haematol.2017.170118DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Prior treatment exposure in patients with relapsed/refractory multiple myeloma may affect outcomes with subsequent therapies. We analyzed efficacy and safety according to prior treatment in the phase 3 TOURMALINE-MM1 study of ixazomib-lenalidomide-dexamethasone (ixazomib-Rd) versus placebo-Rd. Patients with relapsed/refractory multiple myeloma received ixazomib-Rd or placebo-Rd. Efficacy and safety were evaluated in subgroups defined according to type (proteasome inhibitor [PI] and immunomodulatory drug) and number (1 vs. 2 or 3) of prior therapies received. Of 722 patients, 503 (70%) had received a prior PI, and 397 (55%) prior lenalidomide/thalidomide; 425 patients had received 1 prior therapy, and 297 received 2 or 3 prior therapies. At a median follow up of ~15 months, PFS was prolonged with ixazomib-Rd vs. placebo-Rd regardless of type of prior therapy received; HR 0.739 and 0.749 in PI-exposed and -naïve patients, HR 0.744 and 0.700 in immunomodulatory-drug-exposed and -naïve patients, respectively. PFS benefit with ixazomib-Rd vs. placebo-Rd appeared greater in patients with 2 or 3 prior therapies (HR 0.58) and in those with 1 prior therapy without prior transplant (HR 0.60) versus those with 1 prior therapy and transplant (HR 1.23). Across all subgroups, toxicity was consistent with that seen in the intent-to-treat population. In patients with relapsed/refractory multiple myeloma, ixazomib-Rd was associated with a consistent clinical benefit vs. placebo-Rd regardless of prior treatment with bortezomib or immunomodulatory drugs. Patients with 2 or 3 prior therapies, or 1 prior therapy without transplant seemed to have greater benefit than patients with 1 prior therapy and transplant. TOURMALINE-MM1 registered at clinicaltrials.gov identifier: 01564537.
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Masszi, TamasSemmelweis University
(author)
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Grzasko, NorbertMedical University of Lublin
(author)
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Hansson, MarkusLund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital(Swepub:lu)hema-mha
(author)
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Sandhu, IrwindeepUniversity of Alberta
(author)
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Pour, LudekMasaryk University
(author)
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Viterbo, LuísaInstituto Português de Oncologia do Porto Francisco Gentil (IPO)
(author)
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Jackson, Sharon RMiddlemore Hospital, Auckland
(author)
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Stoppa, Anne-MarieInstitut Paoli-Calmettes
(author)
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Gimsing, PeterCopenhagen University Hospital
(author)
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Hamadani, MehdiMedical College of Wisconsin
(author)
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Borsaru, GabrielaColțea Hospital
(author)
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Berg, DeborahTakeda Oncology Inc.
(author)
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Lin, JianchangTakeda Oncology Inc.
(author)
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Di Bacco, AlessandraTakeda Oncology Inc.
(author)
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van de Velde, HelgiTakeda Oncology Inc.
(author)
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Richardson, Paul GDana-Farber Cancer Institute
(author)
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Moreau, PhilippeNantes University Hospital
(author)
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University Hospital of SalamancaSemmelweis University
(creator_code:org_t)
Related titles
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In:Haematologica: Ferrata Storti Foundation (Haematologica)102:10, s. 1767-17751592-87210390-6078
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Mateos, María-Vi ...
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Masszi, Tamas
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Grzasko, Norbert
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Hansson, Markus
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Sandhu, Irwindee ...
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Pour, Ludek
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Viterbo, Luísa
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Jackson, Sharon ...
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Stoppa, Anne-Mar ...
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Gimsing, Peter
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Hamadani, Mehdi
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Borsaru, Gabriel ...
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Berg, Deborah
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Lin, Jianchang
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Di Bacco, Alessa ...
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van de Velde, He ...
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Richardson, Paul ...
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Moreau, Philippe
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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Haematologica
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Lund University