SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Altisent C.)
 

Search: WFRF:(Altisent C.) > Non-genetic risk fa...

  • Astermark, JanLund University,Lunds universitet,Klinisk koagulationsmedicin, Malmö,Forskargrupper vid Lunds universitet,Clinical Coagulation, Malmö,Lund University Research Groups (author)

Non-genetic risk factors and the development of inhibitors in haemophilia: a comprehensive review and consensus report.

  • Article/chapterEnglish2010

Publisher, publication year, extent ...

  • 2010-08-24
  • Wiley,2010

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:5df5bd9f-515a-488c-a18d-0af3bce09042
  • https://lup.lub.lu.se/record/1595156URI
  • https://doi.org/10.1111/j.1365-2516.2010.02231.xDOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Summary. The development of inhibitors to the infused factor in patients with haemophilia is a serious clinical problem. Recent evidence suggests that alongside the strong genetic contribution to inhibitor formation, there are a number of non-genetic factors - perceived by the immune system as danger signals - which promote formation of inhibitors. This study provides a comprehensive review of clinical studies relating to these factors and also presents a survey of opinion concerning their importance and clinical influence, conducted among the members of the European Haemophilia Treatment Standardisation Board (EHTSB). Taken together, this information highlights the lack of robust data concerning the influence of several non-genetic risk factors on inhibitor development, and an urgent need for prospective, well-conducted studies that adhere to recommendations made by the European Medicines Agency (EMEA) for studying inhibitors. Based on current literature, the EHTSB formulated consensus recommendations. It is desirable to minimize intensive treatment wherever possible, given the clinical situation. Prophylaxis should be offered to all children, although we still need to determine optimal dosing with respect to inhibitor development, and age for starting treatment. Vaccinations should be given subcutaneously and concomitant factor concentrate infusions avoided. According to the board, there is no evidence in the literature supporting suggestions that the type of concentrate influences inhibitor risk; but all patients should be monitored during their first exposures. Furthermore, there is no evidence to support an association between pregnancy-related issues, breast feeding and treatment-related factors (e.g. route of administration, or use of blood components) and inhibitor development.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Altisent, C (author)
  • Batorova, A (author)
  • Diniz, M J (author)
  • Gringeri, A (author)
  • Holme, P A (author)
  • Karafoulidou, A (author)
  • Lopez-Fernández, M F (author)
  • Reipert, B M (author)
  • Rocino, A (author)
  • Schiavoni, M (author)
  • von Depka, M (author)
  • Windyga, J (author)
  • Fijnvandraat, K (author)
  • Klinisk koagulationsmedicin, MalmöForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:Haemophilia: WileyMay 4, s. 747-7661351-8216

Internet link

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view