Search: (swepub) lar1:(umu) pers:(Riboli Elio) pers:(Chirlaque Maria Dolores) pers:(Peeters Petra H M) pers:(Bueno de Mesquita H Bas) pers:(Palli Domenico) pers:(Tumino Rosario) pers:(Khaw Kay Tee)
> (2012) >
Multiple Miscarriag...
Multiple Miscarriages Are Associated with the Risk of Ovarian Cancer: Results from the European Prospective Investigation into Cancer and Nutrition
-
Braem, Marieke G. M. (author)
-
Onland-Moret, N. Charlotte (author)
-
Schouten, Leo J. (author)
-
show more...
-
Kruitwagen, Roy F. P. M. (author)
-
Lukanova, Annekatrin (author)
-
Allen, Naomi E. (author)
-
Wark, Petra A. (author)
-
Tjonneland, Anne (author)
-
Hansen, Louise (author)
-
Brauner, Christina Marie (author)
-
Overvad, Kim (author)
-
Clavel-Chapelon, Francoise (author)
-
Chabbert-Buffet, Nathalie (author)
-
Teucher, Birgit (author)
-
Floegel, Anna (author)
-
Boeing, Heiner (author)
-
Trichopoulou, Antonia (author)
-
Adarakis, George (author)
-
Plada, Maria (author)
-
Rinaldi, Sabina (author)
-
Fedirko, Veronika (author)
-
Romieu, Isabelle (author)
-
Pala, Valeria (author)
-
Galasso, Rocco (author)
-
Sacerdote, Carlotta (author)
-
Palli, Domenico (author)
-
Tumino, Rosario (author)
-
Bueno-de-Mesquita, H. Bas (author)
-
Gram, Inger Torhild (author)
-
Gavrilyuk, Oxana (author)
-
Lund, Eiliv (author)
-
Sanchez, Maria-Jose (author)
-
Bonet, Catalina (author)
-
Chirlaque, Maria-Dolores (author)
-
Larranaga, Nerea (author)
-
Barricarte Gurrea, Aurelio (author)
-
Quiros, Jose R. (author)
-
- Idahl, Annika (author)
- Umeå universitet,Obstetrik och gynekologi,Institutionen för folkhälsa och klinisk medicin
-
- Ohlson, Nina (author)
- Umeå universitet,Patologi
-
- Lundin, Eva (author)
- Umeå universitet,Patologi
-
- Jirström, Karin (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
-
- Butt, Salma (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
-
Tsilidis, Konstantinos K. (author)
-
Khaw, Kay-Tee (author)
-
Wareham, Nick (author)
-
Riboli, Elio (author)
-
Kaaks, Rudolf (author)
-
Peeters, Petra H. M. (author)
-
show less...
-
(creator_code:org_t)
- 2012-05-18
- 2012
- English.
-
In: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 7:5
- Related links:
-
https://portal.resea... (primary) (free)
-
show more...
-
http://dx.doi.org/10... (free)
-
https://journals.plo...
-
https://umu.diva-por... (primary) (Raw object)
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- While the risk of ovarian cancer clearly reduces with each full-term pregnancy, the effect of incomplete pregnancies is unclear. We investigated whether incomplete pregnancies (miscarriages and induced abortions) are associated with risk of epithelial ovarian cancer. This observational study was carried out in female participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). A total of 274,442 women were followed from 1992 until 2010. The baseline questionnaire elicited information on miscarriages and induced abortions, reproductive history, and lifestyle-related factors. During a median follow-up of 11.5 years, 1,035 women were diagnosed with incident epithelial ovarian cancer. Despite the lack of an overall association (ever vs. never), risk of ovarian cancer was higher among women with multiple incomplete pregnancies (HR >= 4vs.0: 1.74, 95% CI: 1.20-2.70; number of cases in this category: n = 23). This association was particularly evident for multiple miscarriages (HR >= 4vs.0: 1.99, 95% CI: 1.06-3.73; number of cases in this category: n = 10), with no significant association for multiple induced abortions (HR >= 4vs.0: 1.46, 95% CI: 0.68-3.14; number of cases in this category: n = 7). Our findings suggest that multiple miscarriages are associated with an increased risk of epithelial ovarian cancer, possibly through a shared cluster of etiological factors or a common underlying pathology. These findings should be interpreted with caution as this is the first study to show this association and given the small number of cases in the highest exposure categories.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
-
PLoS ONE
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Braem, Marieke G ...
-
Onland-Moret, N. ...
-
Schouten, Leo J.
-
Kruitwagen, Roy ...
-
Lukanova, Anneka ...
-
Allen, Naomi E.
-
show more...
-
Wark, Petra A.
-
Tjonneland, Anne
-
Hansen, Louise
-
Brauner, Christi ...
-
Overvad, Kim
-
Clavel-Chapelon, ...
-
Chabbert-Buffet, ...
-
Teucher, Birgit
-
Floegel, Anna
-
Boeing, Heiner
-
Trichopoulou, An ...
-
Adarakis, George
-
Plada, Maria
-
Rinaldi, Sabina
-
Fedirko, Veronik ...
-
Romieu, Isabelle
-
Pala, Valeria
-
Galasso, Rocco
-
Sacerdote, Carlo ...
-
Palli, Domenico
-
Tumino, Rosario
-
Bueno-de-Mesquit ...
-
Gram, Inger Torh ...
-
Gavrilyuk, Oxana
-
Lund, Eiliv
-
Sanchez, Maria-J ...
-
Bonet, Catalina
-
Chirlaque, Maria ...
-
Larranaga, Nerea
-
Barricarte Gurre ...
-
Quiros, Jose R.
-
Idahl, Annika
-
Ohlson, Nina
-
Lundin, Eva
-
Jirström, Karin
-
Butt, Salma
-
Tsilidis, Konsta ...
-
Khaw, Kay-Tee
-
Wareham, Nick
-
Riboli, Elio
-
Kaaks, Rudolf
-
Peeters, Petra H ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Other Clinical M ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Obstetrics Gynae ...
- Articles in the publication
-
PLoS ONE
- By the university
-
Lund University
-
Umeå University