SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Sun Yi)
 

Search: WFRF:(Sun Yi) > Cryptococcal Hsf3 c...

  • Gao, XindiNortheastern University (author)

Cryptococcal Hsf3 controls intramitochondrial ROS homeostasis by regulating the respiratory process

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-09-15
  • Springer Science and Business Media LLC,2022

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:5f387dec-f66e-4f4e-adc8-95ad8af8db1f
  • https://lup.lub.lu.se/record/5f387dec-f66e-4f4e-adc8-95ad8af8db1fURI
  • https://doi.org/10.1038/s41467-022-33168-1DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Mitochondrial quality control prevents accumulation of intramitochondrial-derived reactive oxygen species (mtROS), thereby protecting cells against DNA damage, genome instability, and programmed cell death. However, underlying mechanisms are incompletely understood, particularly in fungal species. Here, we show that Cryptococcus neoformans heat shock factor 3 (CnHsf3) exhibits an atypical function in regulating mtROS independent of the unfolded protein response. CnHsf3 acts in nuclei and mitochondria, and nuclear- and mitochondrial-targeting signals are required for its organelle-specific functions. It represses the expression of genes involved in the tricarboxylic acid cycle while promoting expression of genes involved in electron transfer chain. In addition, CnHsf3 responds to multiple intramitochondrial stresses; this response is mediated by oxidation of the cysteine residue on its DNA binding domain, which enhances DNA binding. Our results reveal a function of HSF proteins in regulating mtROS homeostasis that is independent of the unfolded protein response.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Fu, YiNortheastern University (author)
  • Sun, ShengyiNortheastern University (author)
  • Gu, TingyiNortheastern University (author)
  • Li, YanjianNortheastern University (author)
  • Sun, TianshuPeking Union Medical College (author)
  • Li, HailongChina Medical University, Shenyang (author)
  • Du, WeiNortheastern University (author)
  • Suo, ChenhaoNortheastern University (author)
  • Li, ChaoNortheastern University (author)
  • Gao, YiruNortheastern University (author)
  • Meng, YangNortheastern University (author)
  • Ni, YueNortheastern University (author)
  • Yang, ShengNortheastern University (author)
  • Lan, TianNortheastern University (author)
  • Sai, SixiangBinzhou Medical University (author)
  • Li, JiayiLund University,Lunds universitet,Neural plasticitet och reparation,Forskargrupper vid Lunds universitet,Neural Plasticity and Repair,Lund University Research Groups(Swepub:lu)mphy-jli (author)
  • Yu, KunNortheastern University (author)
  • Wang, PingLouisiana State University Health Sciences Center (author)
  • Ding, ChenNortheastern University (author)
  • Northeastern UniversityPeking Union Medical College (creator_code:org_t)

Related titles

  • In:Nature Communications: Springer Science and Business Media LLC13:12041-1723

Internet link

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view