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- Cenci Nilsson, AngelaLund University,Lunds universitet,Basala gangliernas patofysiologi,Forskargrupper vid Lunds universitet,Basal Ganglia Pathophysiology,Lund University Research Groups (author)
Rodent models of treatment-induced motor complications in Parkinson's disease
- Article/chapterEnglish2009
Publisher, publication year, extent ...
- 2009
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:5f53eb8a-071b-45eb-aada-5e3045e47366
- https://lup.lub.lu.se/record/5f53eb8a-071b-45eb-aada-5e3045e47366URI
- https://doi.org/10.1016/S1353-8020(09)70828-4DOI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- Treatment-induced motor complications represent a major clinical problem in Parkinson's disease (PD). Pharmacological dopamine (DA) replacement with l-dopa causes motor fluctuations and abnormal involuntary movements (dyskinesia) in the vast majority of the patients. Intrastriatal grafts of embryonic dopaminergic neurons can cause dyskinesia too, as shown by clinical trials of neural transplantation in PD. Animals models of these complications can be produced in rats and mice in which the nigrostriatal DA pathway has been severely damaged. Rodent models allow investigators to explore mechanistic hypotheses at the cellular and molecular level. Moreover, the rat model of L-dopa-induced abnormal involuntary movements shows both face validity and predictive validity relative to the corresponding disorder in primates, and provides a cost effective tool to evaluate novel antidyskinetic interventions. This article reviews the strategies that have been used to reproduce different motor complications of PD treatment in rodents, and comments on their range of applicability.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
- Animals
- Brain Tissue Transplantation
- Disease Models, Animal
- Dyskinesia, Drug-Induced
- Humans
- Levodopa
- Mice
- Motor Skills Disorders
- Parkinson Disease
- Rats
- Journal Article
- Research Support, Non-U.S. Gov't
- Review
Added entries (persons, corporate bodies, meetings, titles ...)
- Ohlin, ElisabetLund University,Lunds universitet,Basala gangliernas patofysiologi,Forskargrupper vid Lunds universitet,Basal Ganglia Pathophysiology,Lund University Research Groups(Swepub:lu)med-elo (author)
- Basala gangliernas patofysiologiForskargrupper vid Lunds universitet (creator_code:org_t)
Related titles
- In:Parkinsonism and Related Disorders15 Suppl 4, s. 7-131873-5126
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