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  • Covaciu, LucianUppsala universitet,Anestesiologi och intensivvård (författare)

Brain temperature in volunteers subjected to intranasal cooling

  • Artikel/kapitelEngelska2011

Förlag, utgivningsår, omfång ...

  • 2011-06-07
  • Springer Science and Business Media LLC,2011

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:5f61f407-9266-4528-bb00-37581a2f3c99
  • https://lup.lub.lu.se/record/2091583URI
  • https://doi.org/10.1007/s00134-011-2264-7DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-156896URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Intranasal cooling can be used to initiate therapeutic hypothermia. However, direct measurement of brain temperature is difficult and the intra-cerebral distribution of temperature changes with cooling is unknown. The purpose of this study was to measure the brain temperature of human volunteers subjected to intranasal cooling using non-invasive magnetic resonance (MR) methods. Intranasal balloons catheters circulated with saline at 20A degrees C were applied for 60 min in ten awake volunteers. No sedation was used. Brain temperature changes were measured and mapped using MR spectroscopic imaging (MRSI) and phase-mapping techniques. Heart rate and blood pressure were monitored throughout the experiment. Rectal temperature was measured before and after the cooling. Mini Mental State Examination (MMSE) test and nasal inspection were done before and after the cooling. Questionnaires about the subjects' personal experience were completed after the experiment. Brain temperature decrease measured by MRSI was -1.7 +/- A 0.8A degrees C and by phase-mapping -1.8 +/- A 0.9A degrees C (n = 9) at the end of cooling. Spatial distribution of temperature changes was relatively uniform. Rectal temperature decreased by -0.5 +/- A 0.3A degrees C (n = 5). The physiological parameters were stable and no shivering was reported. The volunteers remained alert during cooling and no cognitive dysfunctions were apparent in the MMSE test. Postcooling nasal examination detected increased nasal secretion in nine of the ten volunteers. Volunteers' acceptance of the method was good. Both MR techniques revealed brain temperature reductions after 60 min of intranasal cooling with balloons circulated with saline at 20A degrees C in awake, unsedated volunteers.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Weis, JanUppsala universitet,Enheten för radiologi(Swepub:uu)janweis (författare)
  • Bengtsson, CarolineUppsala universitet,Öron-, näs- och halssjukdomar(Swepub:uu)carbe980 (författare)
  • Allers, M. (författare)
  • Lunderquist, AndersLund University,Lunds universitet,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-alt (författare)
  • Ahlström, HåkanUppsala universitet,Enheten för radiologi(Swepub:uu)hakanahl (författare)
  • Rubertsson, StenUppsala universitet,Anestesiologi och intensivvård(Swepub:uu)stenrube (författare)
  • Uppsala universitetAnestesiologi och intensivvård (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Intensive Care Medicine: Springer Science and Business Media LLC37:8, s. 1277-12840342-46421432-1238

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