The role of RANK-ligand inhibition in cancer : the story of denosumab

• The diagnosis of bone metastases is an event with certain consequences for the patient. They often mean pain and can also mean pathological fractures, hypercalcemia, and spinal cord compression, all synonymous with a diminished quality of life and often also hospitalization. Since the advent of the intravenous bisphosphonates, things began to look a bit brighter for patients with bone metastases-bone destruction was kept at bay a little longer. The next generation of bone metastasis treatments is well on its way in clinical development, and among them, the most advanced drug is denosumab. Denosumab is a fully human monoclonal antibody that inhibits osteoclast maturation, activation, and function by binding to receptor activator of nuclear factor kappa B ligand, with the final result being a reduced rate of bone resorption. In this review, we give an overview of relevant preclinical and clinical data regarding the use of denosumab in patients with solid tumors in general and prostate cancer in particular.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Keyword

Antibodies, Monoclonal

Antibodies, Monoclonal, Humanized

Antineoplastic Agents

Bone Neoplasms

Bone Remodeling

Breast Neoplasms

Clinical Trials as Topic

Denosumab

Humans

Male

Multiple Myeloma

Osteoclasts

Prostatic Neoplasms

RANK Ligand

Receptor Activator of Nuclear Factor-kappa B

Treatment Outcome

Journal Article

Research Support, Non-U.S. Gov't

Review

Publication and Content Type

for (subject category)

ref (subject category)