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Late Mortality afte...
Late Mortality after Allogeneic Bone Marrow Transplantation in Childhood for Bone Marrow Failure Syndromes and Severe Aplastic Anemia
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- Holmqvist, Anna Sällfors (author)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Chen, Yanjun (author)
- University of Alabama
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- Wu, Jessica (author)
- University of Alabama
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- Battles, Kevin (author)
- University of Alabama
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- Francisco, Liton (author)
- University of Alabama
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- Hageman, Lindsey (author)
- University of Alabama
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- Kung, Michelle (author)
- University of Alabama
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- Ness, Emily (author)
- University of Alabama
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- Parman, Mariel (author)
- University of Alabama
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- Winther, Jeanette Falck (author)
- Danish Cancer Society,Aarhus University
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- Rosenthal, Joseph (author)
- City of Hope National Medical Center
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- Arora, Mukta (author)
- University of Minnesota
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- Armenian, Saro H. (author)
- City of Hope National Medical Center
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- Bhatia, Smita (author)
- University of Alabama
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(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- English.
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In: Biology of Blood and Marrow Transplantation. - : Elsevier BV. - 1083-8791. ; 25:4, s. 749-755
- Related links:
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http://dx.doi.org/10...
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http://www.bbmt.org/...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- Children with bone marrow failure syndromes and severe aplastic anemia (SAA) are treated with allogeneic blood or marrow transplantation (BMT). However, there is a paucity of studies examining late mortality risk after allogeneic BMT performed in childhood for bone marrow failure syndromes and SAA and evaluating how this risk differs between these diseases. We investigated cause-specific late mortality in 2-year survivors of allogeneic BMT for bone marrow failure syndromes and SAA performed before age 22 years between 1974 and 2010 at 2 US transplantation centers. Vital status information was collected from medical records, the National Death Index, and Accurint databases. Overall survival was calculated using Kaplan-Meier techniques. The standardized mortality ratio (SMR) was calculated using age- sex-, and calendar-specific mortality rates from the Centers for Disease Control and Prevention. Among the 2-year survivors of bone marrow failure syndromes (n = 120) and SAA (n = 147), there were 15 and 19 deaths, respectively, yielding an overall survival of 86.4% for bone marrow failure syndromes and 93.1% for SAA at 15 years post-BMT. Compared with the general population, patients with bone marrow failure syndromes were at a higher risk for premature death (SMR, 22.7; 95% CI, 13.1 to 36.2) compared with those with SAA (SMR, 4.5; 95% CI, 2.8 to 7.0) (P <.0001). The elevated relative risk persisted at ≥15 years after BMT for both diseases. The hazard of all-cause late mortality was 2.9-fold (95% CI, 1.1 to 7.3) higher in patients with bone marrow failure syndromes compared with those with SAA. The high late mortality risk in recipients of allogeneic BMT in childhood for bone marrow failure syndromes calls for intensified life-long follow-up.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Allogeneic BMT
- Bone marrow failure syndrome
- Childhood
- Late mortality
- Severe aplastic anemia
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Holmqvist, Anna ...
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Chen, Yanjun
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Wu, Jessica
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Battles, Kevin
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Francisco, Liton
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Hageman, Lindsey
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show more...
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Kung, Michelle
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Ness, Emily
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Parman, Mariel
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Winther, Jeanett ...
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Rosenthal, Josep ...
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Arora, Mukta
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Armenian, Saro H ...
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Bhatia, Smita
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show less...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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Biology of Blood ...
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Lund University