Estimating driver risk using alcohol biomarkers, interlock blood alcohol concentration tests and psychometric assessments: initial descriptives

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Marques, Paul (author)

Estimating driver risk using alcohol biomarkers, interlock blood alcohol concentration tests and psychometric assessments: initial descriptives

Article/chapterEnglish2010

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Wiley,2010

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LIBRIS-ID:oai:lup.lub.lu.se:5fbd6c8f-6e9f-40e9-bded-cc1edefe22ff
https://lup.lub.lu.se/record/1547720URI
https://doi.org/10.1111/j.1360-0443.2009.02738.xDOI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

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Aim To identify alcohol biomarker and psychometric measures that relate to drivers' blood alcohol concentration (BAC) patterns from ignition interlock devices (IIDs). Design, setting, participants, measurements In Alberta, Canada, 534 drivers, convicted of driving under the influence of alcohol (DUI), installed IIDs and agreed to participate in a research study. IID BAC tests are an established proxy for predicting future DUI convictions. Three risk groups were defined by rates of failed BAC tests. Program entry and follow-up blood samples (n = 302, 171) were used to measure phosphatidyl ethanol (PETH), carbohydrate deficient transferrin (%CDT), gamma glutamyltransferase (GGT) and other biomarkers. Program entry urine (n = 130) was analyzed for ethyl glucuronide (ETG) and ethyl sulphate (ETS). Entry hair samples were tested for fatty acid ethyl esters (FAEE) (n = 92) and ETG (n = 146). Psychometric measures included the DSM-4 Diagnostic Interview Schedule Alcohol Module, Alcohol Use Disorders Identification Test (AUDIT), the time-line follow-back (TLFB), the Drinker Inventory of Consequences (DRINC) and the Temptation and Restraint Inventory (TRI). Findings Except for FAEE, all alcohol biomarkers were related significantly to the interlock BAC test profiles; higher marker levels predicted higher rates of interlock BAC test failures. PETH, the strongest with an overall analysis of variance F ratio of 35.5, had significant correlations with all nine of the other alcohol biomarkers and with 16 of 19 psychometric variables. Urine ETG and ETS were correlated strongly with the IID BAC tests. Conclusions The findings suggest that several alcohol biomarkers and assessments could play an important role in the prediction and control of driver alcohol risk when re-licensing.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Beroendelära hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Substance Abuse hsv//eng
ignition interlock
DUI
driver
biomarkers
Alcohol
assessment
phosphatidyl ethanol (PETH)

Added entries (persons, corporate bodies, meetings, titles ...)

Tippetts, Scott (author)
Allen, John (author)
Javors, Martin (author)
Alling, ChristerLund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)pneu-cal (author)
Yegles, Michel (author)
Pragst, Fritz (author)
Wurst, Friedrich (author)
Avdelningen för klinisk kemi och farmakologiInstitutionen för laboratoriemedicin (creator_code:org_t)

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In:Addiction: Wiley105:2, s. 226-2391360-04430965-2140

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By the author/editor: Marques, Paul; Tippetts, Scott; Allen, John; Javors, Martin; Alling, Christer; Yegles, Michel; show more...; Pragst, Fritz; Wurst, Friedrich; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Substance Abuse

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By the university: Lund University

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