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C-Reactive Protein ...
C-Reactive Protein Levels in Systemic Lupus Erythematosus Are Modulated by the Interferon Gene Signature and CRP Gene Polymorphism rs1205
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- Enocsson, Helena (författare)
- Linköpings universitet,Linköping University,Linköping Univ, Dept Biomed & Clin Sci, Div Inflammat & Infect, Linköping, Sweden.,Avdelningen för inflammation och infektion,Medicinska fakulteten
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- Gullstrand, Birgitta (författare)
- Lund University,Lunds universitet,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Lund University Research Groups,Lund Univ, Dept Clin Sci Lund, Div Rheumatol, Lund, Sweden.
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- Eloranta, Maija-Leena (författare)
- Uppsala universitet,Uppsala University,Reumatologi,Uppsala Univ, Sweden
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- Wetterö, Jonas (författare)
- Linköpings universitet,Linköping University,Linköping Univ, Dept Biomed & Clin Sci, Div Inflammat & Infect, Linköping, Sweden.,Avdelningen för inflammation och infektion,Medicinska fakulteten
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- Leonard, Dag, 1975- (författare)
- Uppsala universitet,Uppsala University,Reumatologi,Uppsala Univ, Sweden
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- Rönnblom, Lars (författare)
- Uppsala universitet,Uppsala University,Reumatologi,Uppsala Univ, Sweden
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- Bengtsson, Anders A. (författare)
- Lund University,Lunds universitet,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Lund University Research Groups,Lund Univ, Dept Clin Sci Lund, Div Rheumatol, Lund, Sweden.
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- Sjöwall, Christopher (författare)
- Linköpings universitet,Linköping University,Linköping Univ, Dept Biomed & Clin Sci, Div Inflammat & Infect, Linköping, Sweden.,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland
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Linköping University Linköping Univ, Dept Biomed & Clin Sci, Div Inflammat & Infect, Linköping, Sweden (creator_code:org_t)
- 2021-01-28
- 2021
- Engelska.
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Ingår i: Frontiers in Immunology. - : Frontiers Media SA. - 1664-3224. ; 11
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://www.frontier...
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://liu.diva-por... (primary) (Raw object)
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Objectives: Patients with systemic lupus erythematosus (SLE) often display modest elevations of C-reactive protein (CRP) despite raised disease activity and increased interleukin (IL-) 6. We asked to what extent IL-6 levels, the CRP polymorphism rs1205, and the type I interferon (IFN) gene signature affects the basal CRP levels in patients with SLE during a quiescent phase of the disease. Methods: CRP and IL-6 were analyzed in plasma from 57 patients meeting established classification criteria for SLE. The CRP polymorphism rs1205 was assessed and gene expression analyzed including four type I IFN-regulated genes (IGS). Results: CRP was increased in patients with detectable IL-6 levels (p=0.001) and decreased among IGS-positive subjects (p=0.033). A multiple linear regression model revealed IL-6 to have a positive association with CRP levels, whereas both IGS-positivity and CRP genotype (rs1205) AA/GA were negatively associated with CRP-levels. Conclusion: Our data offer an explanation to the modest CRP levels seen in viral infections and IFN-α driven autoimmunity and corroborate prior observations showing an IFN-α dependent downregulation of CRP. The latter observation, together with the fact that the CRP-lowering polymorphism rs1205 is overrepresented in human SLE, could explain low basal CRP and inadequate CRP-responses among patients with active SLE.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- biomarker
- C-reactive protein
- gene variants
- inflammation
- interferon
- pentraxins
- systemic lupus erythematosus
- type I interferons
- C-reactive protein
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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