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- Lindblom, Rickard,1981-Uppsala universitet,Uppsala University,Uppsala University Hospital,Thoraxkirurgi (author)
Mechanical Reperfusion Following Prolonged Global Cerebral Ischemia Attenuates Brain Injury
- Article/chapterEnglish2021
Publisher, publication year, extent ...
- 2020-07-17
- Springer Science and Business Media LLC,2021
- 10 s.
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:6079f74d-7ce3-4d9b-bc13-c0c7d7a6fdb9
- https://lup.lub.lu.se/record/6079f74d-7ce3-4d9b-bc13-c0c7d7a6fdb9URI
- https://doi.org/10.1007/s12265-020-10058-9DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-450612URI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- Previous experiments demonstrated improved outcome following prolonged cerebral ischemia given controlled brain reperfusion using extracorporeal circulation. The current study further investigates this. Young adult pigs were exposed to 30 min of global normothermic cerebral ischemia, achieved through intrathoracic clamping of cerebral arteries, followed by 20 min of isolated mechanical brain reperfusion. Leukocyte-filtered blood was delivered by a roller-pump at fixed pressure and flow. One experimental group additionally had a custom-made buffer solution delivered at 1:8 ratio with the blood. Hemodynamics including intracranial pressure were monitored. Blood gases were from peripheral arteries and the sagittal sinus, and intraparenchymal brain microdialysis was performed. The brains were examined by a neuropathologist. The group with the added buffer showed lower intracranial pressure as well as decreased intraparenchymal glycerol and less signs of excitotoxicity and ischemia, although histology revealed similar degrees of injury. A customized mechanical reperfusion improves multiple parameters after prolonged normothermic global cerebral ischemia. [Figure not available: see fulltext.]
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Anestesi och intensivvård hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Anesthesiology and Intensive Care hsv//eng
- Global cerebral ischemia
- Mechanical circulation
- Reperfusion
- Global cerebral ischemia
Added entries (persons, corporate bodies, meetings, titles ...)
- Tovedal, Thomas,1955-Uppsala universitet,Uppsala University,Uppsala University Hospital,Anestesiologi och intensivvård(Swepub:uu)thoto732 (author)
- Norlin, BoUppsala University Hospital,Uppsala Univ Hosp, Dept Cardiothorac Surg & Anesthesia, SE-75185 Uppsala, Sweden. (author)
- Hillered, Lars,1952-Uppsala universitet,Uppsala University,Enblad: Neurokirurgi(Swepub:uu)larshill (author)
- Englund, ElisabetLund University,Lunds universitet,Patologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Pathology, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Dept Clin Sci, Lund, Sweden.(Swepub:lu)pat-een (author)
- Thelin, StefanUppsala universitet,Uppsala University,Uppsala University Hospital,Thoraxkirurgi(Swepub:uu)stthe227 (author)
- Uppsala UniversityUppsala University Hospital (creator_code:org_t)
Related titles
- In:Journal of Cardiovascular Translational Research: Springer Science and Business Media LLC14:2, s. 338-3471937-53871937-5395
Internet link
- http://dx.doi.org/10.1007/s12265-020-10058-9FULLTEXT
- https://link.springer.com/content/pdf/10.1007/s12265-020-10058-9.pdf
- https://doi.org/10.1007/s12265-020-10058-9Fulltext
- https://uu.diva-portal.org/smash/get/diva2:1585617/FULLTEXT01.pdffulltext:print
- https://lup.lub.lu.se/record/6079f74d-7ce3-4d9b-bc13-c0c7d7a6fdb9
- https://doi.org/10.1007/s12265-020-10058-9
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-450612
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