Small cells – big issues : biological implications and preclinical advancements in small cell lung cancer

Current treatment guidelines refer to small cell lung cancer (SCLC), one of the deadliest human malignancies, as a homogeneous disease. Accordingly, SCLC therapy comprises chemoradiation with or without immunotherapy. Meanwhile, recent studies have made significant advances in subclassifying SCLC based on the elevated expression of the transcription factors ASCL1, NEUROD1, and POU2F3, as well as on certain inflammatory characteristics. The role of the transcription regulator YAP1 in defining a unique SCLC subset remains to be established. Although preclinical analyses have described numerous subtype-specific characteristics and vulnerabilities, the so far non-existing clinical subtype distinction may be a contributor to negative clinical trial outcomes. This comprehensive review aims to provide a framework for the development of novel personalized therapeutic approaches by compiling the most recent discoveries achieved by preclinical SCLC research. We highlight the challenges faced due to limited access to patient material as well as the advances accomplished by implementing state-of-the-art models and methodologies.

Ernhofer, BüsraMedical University of Vienna (author)
Boettiger, KristiinaMedical University of Vienna (author)
Megyesfalvi, ZsoltNational Korányi Institute for Tuberculosis and Pulmonology, Hungary,National Institute of Oncology, Budapest,Medical University of Vienna (author)
Heeke, SimonUniversity of Texas (author)
Hoda, Mir AlirezaMedical University of Vienna (author)
Lang, ChristianMedical University of Vienna (author)
Aigner, ClemensMedical University of Vienna (author)
Hirsch, Fred R.University of Colorado School of Medicine,Icahn School of Medicine at Mount Sinai (author)
Schelch, KarinMedical University of Vienna (author)
Döme, BalazsLund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups,National Institute of Oncology, Budapest,National Korányi Institute for Tuberculosis and Pulmonology, Hungary,Medical University of Vienna(Swepub:lu)ba1464do (author)
Medical University of ViennaNational Korányi Institute for Tuberculosis and Pulmonology, Hungary (creator_code:org_t)

By the author/editor: Solta, Anna; Ernhofer, Büsra; Boettiger, Krist ...; Megyesfalvi, Zso ...; Heeke, Simon; Hoda, Mir Alirez ...; show more...; Lang, Christian; Aigner, Clemens; Hirsch, Fred R.; Schelch, Karin; Döme, Balazs; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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