Light Responsiveness and Assembly of Arylazopyrazole-Based Surfactants in Neat and Mixed CTAB Micelles

The self-assembly of an arylazopyrazole-based photosurfactant (PS), based on cetyltrimethylammonium bromide (CTAB), and its mixed micelle formation with CTAB in aqueous solution was investigated by small angle neutron and X-ray scattering (SANS/SAXS) and UV-vis absorption spectroscopy. Upon UV light exposure, PS photoisomerizes from E-PS (trans) to Z-PS (cis), which transforms oblate ellipsoidal micelles into smaller, spherical micelles with larger shell thickness. Doping PS with CTAB resulted in mixed micelle formation at all stoichiometries and conditions investigated; employing selectively deuterated PS, a monotonic variation in scattering length density and dimensions of the micellar core and shell is observed for all contrasts. The concentration- and irradiance-dependence of the E to Z configurational transition was established in both neat and mixed micelles. A liposome dye release assay establishes the enhanced efficacy of photosurfactants at membrane disruption, with E-PS exhibiting a 4-fold and Z-PS a 10-fold increase in fluorescence signal with respect to pure CTAB. Our findings pave the way for external triggering and modulation of the wide range of CTAB-based biomedical and material applications.

Greenfield, Jake L.Imperial College London (författare)
Jones, Beatrice E.University of Cambridge,Diamond Light Source (författare)
Sharratt, William N.Imperial College London (författare)
Khan, KasimLund University,Lunds universitet,Molekylär cellbiologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Växtbiologi,Forskargrupper vid Lunds universitet,Molecular Cell Biology,Department of Biology,Faculty of Science,Plant Biology,Lund University Research Groups(Swepub:lu)ka5632kh (författare)
Seddon, DaleImperial College London (författare)
Malone, Lorna A.Diamond Light Source (författare)
Cowieson, NathanDiamond Light Source (författare)
Evans, Rachel C.University of Cambridge (författare)
Fuchter, Matthew J.Imperial College London (författare)
Cabral, João T.Imperial College London (författare)
Imperial College LondonUniversity of Cambridge (creator_code:org_t)

Ingår i:Journal of the American Chemical Society: American Chemical Society (ACS)2:12, s. 2670-26770002-7863
Ingår i:JACS Au: American Chemical Society (ACS)2:12, s. 2670-26772691-37042691-3704

Av författaren/redakt...: Tyagi, Gunjan; Greenfield, Jake ...; Jones, Beatrice ...; Sharratt, Willia ...; Khan, Kasim; Seddon, Dale; visa fler...; Malone, Lorna A.; Cowieson, Nathan; Evans, Rachel C.; Fuchter, Matthew ...; Cabral, João T.; visa färre...

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