Search: onr:"swepub:oai:lup.lub.lu.se:6183ba7b-3d2b-4a89-8014-4f75405582aa" >
Multi-ancestry geno...
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Pervjakova, NataliaTartu University Hospital
(author)
Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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2022-02-26
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Oxford University Press (OUP),2022
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:6183ba7b-3d2b-4a89-8014-4f75405582aa
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https://lup.lub.lu.se/record/6183ba7b-3d2b-4a89-8014-4f75405582aaURI
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https://doi.org/10.1093/hmg/ddac050DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Gestational diabetes mellitus (GDM) is associated with increased risk of pregnancy complications and adverse perinatal outcomes. GDM often reoccurs and is associated with increased risk of subsequent diagnosis of type 2 diabetes (T2D). To improve our understanding of the aetiological factors and molecular processes driving the occurrence of GDM, including the extent to which these overlap with T2D pathophysiology, the GENetics of Diabetes In Pregnancy (GenDIP) Consortium assembled genome-wide association studies (GWAS) of diverse ancestry in a total of 5485 women with GDM and 347 856 without GDM. Through multi-ancestry meta-analysis, we identified five loci with genome-wide significant association (p < 5x10-8) with GDM, mapping to/near MTNR1B (p = 4.3x10-54), TCF7L2 (p = 4.0x10-16), CDKAL1 (p = 1.6 × 10-14), CDKN2A-CDKN2B (p = 4.1x10-9) and HKDC1 (p = 2.9x10-8). Multiple lines of evidence pointed to the shared pathophysiology of GDM and T2D: (i) four of the five GDM loci (not HKDC1) have been previously reported at genome-wide significance for T2D; (ii) significant enrichment for associations with GDM at previously reported T2D loci; (iii) strong genetic correlation between GDM and T2D; and (iv) enrichment of GDM associations mapping to genomic annotations in diabetes-relevant tissues and transcription factor binding sites. Mendelian randomisation analyses demonstrated significant causal association (5% false discovery rate) of higher body mass index on increased GDM risk. Our results provide support for the hypothesis that GDM and T2D are part of the same underlying pathology but that, as exemplified by the HKDC1 locus, there are genetic determinants of GDM that are specific to glucose regulation in pregnancy.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Moen, Gunn-HelenUniversity of Oslo
(author)
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Borges, Maria-CarolinaUniversity of Bristol
(author)
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Ferreira, TeresaUniversity of Oxford
(author)
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Cook, James PUniversity of Liverpool
(author)
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Allard, CatherineSherbrooke University
(author)
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Beaumont, Robin NUniversity of Exeter
(author)
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Canouil, MickaëlPasteur Institute of Lille
(author)
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Hatem, GadLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups(Swepub:lu)ga5503ha
(author)
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Heiskala, AnniUniversity of Oulu
(author)
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Joensuu, AnniFinnish National Institute for Health and Welfare
(author)
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Karhunen, VilleUniversity of Oulu
(author)
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Kwak, Soo Heon
(author)
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Lin, Frederick T J
(author)
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Liu, Jun
(author)
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Rifas-Shiman, Sheryl
(author)
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Tam, Claudia H
(author)
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Tam, Wing Hung
(author)
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Thorleifsson, Gudmar
(author)
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Andrew, Toby
(author)
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Auvinen, Juha
(author)
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Bhowmik, Bishwajit
(author)
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Bonnefond, Amélie
(author)
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Delahaye, Fabien
(author)
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Demirkan, Ayse
(author)
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Froguel, Philippe
(author)
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Haller-Kikkatalo, Kadri
(author)
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Hardardottir, Hildur
(author)
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Hummel, Sandra
(author)
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Hussain, Akhtar
(author)
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Kajantie, Eero
(author)
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Keikkala, Elina
(author)
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Khamis, Amna
(author)
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Lahti, Jari
(author)
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Lekva, Tove
(author)
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Mustaniemi, Sanna
(author)
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Sommer, Christine
(author)
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Tagoma, Aili
(author)
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Tzala, Evangelia
(author)
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Uibo, RaivoUniversity of Tartu(Swepub:lu)med-ruo
(author)
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Vääräsmäki, Marja
(author)
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Villa, Pia M
(author)
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Birkeland, Kåre I
(author)
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Bouchard, Luigi
(author)
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Duijn, Cornelia M
(author)
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Finer, Sarah
(author)
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Groop, LeifLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Helsinki(Swepub:lu)endo-lgr
(author)
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Hämäläinen, Esa
(author)
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Hayes, Geoffrey M
(author)
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Hitman, Graham A
(author)
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Jang, Hak C
(author)
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Järvelin, Marjo-Riitta
(author)
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Jenum, Anne Karen
(author)
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Laivuori, Hannele
(author)
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Ma, Ronald C
(author)
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Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome
(author)
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Oken, Emily
(author)
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Park, Kyong Soo
(author)
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Perron, Patrice
(author)
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Prasad, Rashmi BLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups(Swepub:lu)med-rpa
(author)
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Qvigstad, Elisabeth
(author)
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Sebert, Sylvain
(author)
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Stefansson, Kari
(author)
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Steinthorsdottir, Valgerdur
(author)
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Tuomi, TiinamaijaLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Folkhälsan Research Center,Helsinki University Central Hospital,University of Helsinki(Swepub:lu)ti8736tu
(author)
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Hivert, Marie-France
(author)
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Franks, Paul WLund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Harvard University(Swepub:lu)med-plf
(author)
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McCarthy, Mark I
(author)
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Lindgren, Cecilia MUniversity of Oxford,Broad Institute(Swepub:lu)endo-cli
(author)
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Freathy, Rachel M
(author)
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Lawlor, Deborah A
(author)
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Morris, Andrew P
(author)
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Mägi, Reedik
(author)
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Tartu University HospitalUniversity of Oslo
(creator_code:org_t)
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In:Human Molecular Genetics: Oxford University Press (OUP)31:19, s. 3377-33910964-69061460-2083
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Pervjakova, Nata ...
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Moen, Gunn-Helen
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Borges, Maria-Ca ...
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Ferreira, Teresa
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Cook, James P
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Allard, Catherin ...
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Beaumont, Robin ...
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Canouil, Mickaël
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Hatem, Gad
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Heiskala, Anni
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Joensuu, Anni
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Karhunen, Ville
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Kwak, Soo Heon
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Lin, Frederick T ...
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Liu, Jun
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Rifas-Shiman, Sh ...
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Tam, Claudia H
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Tam, Wing Hung
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Thorleifsson, Gu ...
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Andrew, Toby
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Auvinen, Juha
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Bhowmik, Bishwaj ...
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Bonnefond, Améli ...
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Delahaye, Fabien
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Demirkan, Ayse
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Froguel, Philipp ...
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Haller-Kikkatalo ...
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Hardardottir, Hi ...
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Hummel, Sandra
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Hussain, Akhtar
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Kajantie, Eero
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Keikkala, Elina
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Khamis, Amna
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Lahti, Jari
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Lekva, Tove
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Mustaniemi, Sann ...
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Sommer, Christin ...
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Tagoma, Aili
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Tzala, Evangelia
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Uibo, Raivo
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Vääräsmäki, Marj ...
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Villa, Pia M
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Birkeland, Kåre ...
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Bouchard, Luigi
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Duijn, Cornelia ...
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Finer, Sarah
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Groop, Leif
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Hämäläinen, Esa
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Hayes, Geoffrey ...
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Hitman, Graham A
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Jang, Hak C
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Järvelin, Marjo- ...
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Jenum, Anne Kare ...
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Laivuori, Hannel ...
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Ma, Ronald C
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Melander, Olle
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Oken, Emily
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Park, Kyong Soo
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Perron, Patrice
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Prasad, Rashmi B
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Qvigstad, Elisab ...
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Sebert, Sylvain
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Stefansson, Kari
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Steinthorsdottir ...
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Tuomi, Tiinamaij ...
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Hivert, Marie-Fr ...
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Franks, Paul W
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McCarthy, Mark I
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Lindgren, Cecili ...
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Freathy, Rachel ...
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Lawlor, Deborah ...
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Morris, Andrew P
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Mägi, Reedik
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