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Sökning: WFRF:(Shaat Nael) > (2020-2023) > Diagnosis of Gestat...

Diagnosis of Gestational Diabetes Mellitus with Point-of-Care Methods for Glucose versus Hospital Laboratory Method Using Isotope Dilution Gas Chromatography-Mass Spectrometry as Reference

Kristensen, Karl (författare)
Lund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Obstetrics and Gynecology, Skåne University Hospital, Malmö, Sweden; Department of Clinical Sciences Lund, Lund University, Lund, Sweden,Skane Univ Hosp, Dept Obstet & Gynecol, Malmo, Sweden.;Lund Univ, Dept Clin Sci Lund, Lund, Sweden.
Wangel, Anne-Marie (författare)
Malmö universitet,Malmö University,Faculty of Health and Society, Department of Care Science, Malmö University, Malmö, Sweden,Institutionen för vårdvetenskap (VV)
Katsarou, Anastasia (författare)
Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Department of Endocrinology, Skåne University Hospital, Malmö, Sweden; Department of Clinical Sciences Malmö, Lund University, Lund, Sweden,Skane Univ Hosp, Dept Endocrinol, Malmo, Sweden.;Lund Univ, Dept Clin Sci Malmo, Lund, Sweden.
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Shaat, Nael (författare)
Lund University,Lunds universitet,Translationell Muskel Forskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Department of Endocrinology, Skåne University Hospital, Malmö, Sweden; Department of Clinical Sciences Malmö, Lund University, Lund, Sweden,Skane Univ Hosp, Dept Endocrinol, Malmo, Sweden.;Lund Univ, Dept Clin Sci Malmo, Lund, Sweden.
Simmons, David, 1959- (författare)
Örebro universitet,Örebro University,Macarthur Clinical School, Western Sydney University, Campbelltown, Australia; Department of Obstetrics and Gynecology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Institutionen för medicinska vetenskaper,Univ Western Sydney, Macarthur Clin Sch, Campbelltown, NSW, Australia.;Orebro Univ, Dept Obstet & Gynecol, Fac Med & Hlth, Orebro, Sweden.
Fadl, Helena, 1965- (författare)
Örebro universitet,Örebro University,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Obstetrics and Gynecology,Orebro Univ, Dept Obstet & Gynecol, Fac Med & Hlth, Orebro, Sweden.
Berntorp, Kerstin (författare)
Lund University,Lunds universitet,Translationell Muskel Forskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Department of Endocrinology, Skåne University Hospital, Malmö, Sweden; Department of Clinical Sciences Malmö, Lund University, Lund, Sweden,Skane Univ Hosp, Dept Endocrinol, Malmo, Sweden.;Lund Univ, Dept Clin Sci Malmo, Lund, Sweden.
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 (creator_code:org_t)
Hindawi Limited, 2020
2020
Engelska.
Ingår i: Journal of Diabetes Research. - : Hindawi Limited. - 2314-6745 .- 2314-6753. ; 2020
Relaterad länk:
http://dx.doi.org/10... (free)
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https://doi.org/10.1...
https://doi.org/10.1...
https://mau.diva-por... (primary) (Raw object)
https://lup.lub.lu.s...
https://doi.org/10.1...
https://urn.kb.se/re...
https://urn.kb.se/re...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background. In Sweden, both glucose analyzers in accredited laboratories and point-of-care glucose devices are used for gestational diabetes mellitus (GDM) diagnosis. The aim of this study was to compare the diagnostic performance of the HemoCue Glucose 201+ (HC201+) and RT (HC201RT) systems with that of the hospital central laboratory hexokinase method (CL) based on lyophilized citrate tubes, using the isotope dilution gas chromatography-mass spectrometry (ID GC-MS) as reference. Methods. A 75 g oral glucose tolerance test was performed on 135 women screened positive for GDM. Diagnosis was based on the World Health Organization 2013 diagnostic thresholds for fasting (n=135), 1 h (n=52), and 2 h (n=135) glucose measurements. Bland-Altman analysis and surveillance error grids were used to evaluate analytical and clinical accuracy. Results. Significantly more women were diagnosed with GDM by HC201+ (80%) and CL (80%) than with the reference (65%, P<0.001) based on fasting and/or 2 h thresholds, whereas the percentage diagnosed by HC201RT (60%) did not differ significantly from the reference. In Bland-Altman analysis, a positive bias was observed for HC201+ (4.2%) and CL (6.1%) and a negative bias for HC201RT (-1.8%). In the surveillance error grid, 95.9% of the HC201+ values were in the no-risk zone as compared to 98.1% for HC201RT and 97.5% for CL. Conclusions. A substantial positive bias was found for CL measurements resulting in overdiagnosis of GDM. Our findings suggest better performance of HC201RT than HC201+ in GDM diagnosis. The results may have possible implications for GDM diagnosis in Sweden and require further elucidation.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
TEKNIK OCH TEKNOLOGIER  -- Medicinteknik -- Medicinsk laboratorie- och mätteknik (hsv//swe)
ENGINEERING AND TECHNOLOGY  -- Medical Engineering -- Medical Laboratory and Measurements Technologies (hsv//eng)

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