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The pharmacokinetic...
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Grinyo, Josep M.
(author)
The pharmacokinetics of mycophenolate mofetil in renal transplant recipients receiving standard-dose or low-dose cyclosporine, low-dose tacrolimus or low-dose sirolimus: the Symphony pharmacokinetic substudy
- Article/chapterEnglish2009
Publisher, publication year, extent ...
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2009-04-08
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Oxford University Press (OUP),2009
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:63c97df6-5ae8-4eb8-8261-af4f6bcc8f09
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https://lup.lub.lu.se/record/1441202URI
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https://doi.org/10.1093/ndt/gfp162DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Methods. A 3-month pharmacokinetic substudy of the prospective, randomized, multicentre, open-label Symphony study was performed. Eighty-three adult renal transplant patients received standard-dose cyclosporine, MMF 2 g/day and corticosteroids, or daclizumab induction, MMF 2 g/day and corticosteroids plus low-dose cyclosporine, low-dose tacrolimus or low-dose sirolimus. The area under the concentration-time curve (AUC(0-12)) of MPA and its metabolites between treatment groups was compared. Pharmacokinetic sampling was performed before MMF administration and at 20, 40, 75 min; 2, 3, 6, 8, 10 and 12 h post-dose on Day 7 and Months 1 and 3. Results. Compared with standard-dose cyclosporine, patients receiving low-dose tacrolimus or low-dose sirolimus had significantly higher AUC(0-12) values for MPA at Day 7 and Month 1 and for free MPA at Day 7, and significantly lower AUC(0-12) values for 7-O-MPA-glucuronide (MPAG) at Month 1 and for acyl-glucuronide at Months 1 and 3 (P < 0.05). AUC(0-12) of MPA and free MPA was significantly greater with low-dose tacrolimus and low-dose sirolimus than with low-dose cyclosporine in the first month (P < 0.05). The ratio of MPA to MPAG exposure was significantly higher in the three low-dose groups than in the standard-dose cyclosporine group (P < 0.05). Conclusions. Standard- and low-dose cyclosporine reduces the exposure of MPA and free MPA compared to low-dose tacrolimus or low-dose sirolimus in patients given the same dose of MMF.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Ekberg, HenrikLund University,Lunds universitet,Enheten för forskning kring njurfunktion och njursjukdom,Kirurgi,Forskargrupper vid Lunds universitet,Renal Research Unit,Surgery,Lund University Research Groups(Swepub:lu)kir-hek
(author)
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Mamelok, Richard D.
(author)
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Oppenheimer, Federico
(author)
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Sanchez-Plumed, Jaime
(author)
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Angel Gentil, Miguel
(author)
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Hernandez, Domingo
(author)
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Kuypers, Dirk R.
(author)
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Brunet, Merce
(author)
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Enheten för forskning kring njurfunktion och njursjukdomKirurgi
(creator_code:org_t)
Related titles
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In:Nephrology Dialysis Transplantation: Oxford University Press (OUP)24:7, s. 2269-22761460-23850931-0509
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