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A lifestyle interve...
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Sanllorente, AlbertHospital del Mar Medical Research Institute,Carlos III Health Institute,Pompeu Fabra University
(author)
A lifestyle intervention with an energy-restricted Mediterranean diet and physical activity enhances HDL function : a substudy of the PREDIMED-Plus randomized controlled trial
- Article/chapterEnglish2021
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LIBRIS-ID:oai:lup.lub.lu.se:63e387f8-6cbe-4bad-92a1-582ac6a90b50
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https://lup.lub.lu.se/record/63e387f8-6cbe-4bad-92a1-582ac6a90b50URI
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https://doi.org/10.1093/ajcn/nqab246DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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BACKGROUND: Consumption of a Mediterranean diet, adequate levels of physical activity, and energy-restricted lifestyle interventions have been individually associated with improvements in HDL functions. Evidence of intensive interventions with calorie restriction and physical activity is, however, scarce. OBJECTIVES: To determine whether an intensive lifestyle intervention with an energy-restricted Mediterranean diet plus physical activity enhanced HDL function compared to a non-hypocaloric Mediterranean eating pattern without physical activity. METHODS: In 391 older adults with metabolic syndrome (mean age, 65 years; mean BMI, 33.3 kg/m2) from 1 of the Prevención con Dieta Mediterránea-Plus trial centers, we evaluated the impact of a 6-month intervention with an energy-restricted Mediterranean diet plus physical activity (intensive lifestyle; n = 190) relative to a nonrestrictive Mediterranean diet without physical activity (control; n = 201) on a set of HDL functional traits. These included cholesterol efflux capacity, HDL oxidative/inflammatory index, HDL oxidation, and levels of complement component 3, serum amyloid A, sphingosine-1-phosphate, triglycerides, and apolipoproteins A-I, A-IV, C-III, and E in apoB-depleted plasma. RESULTS: The intensive-lifestyle intervention participants displayed greater 6-month weight reductions (-3.83 kg; 95% CI: -4.57 to -3.09 kg) but no changes in HDL cholesterol compared with control-diet participants. Regarding HDL functional traits, the intensive lifestyle decreased triglyceride levels (-0.15 mg/g protein; 95% CI: -0.29 to -0.014 mg/g protein) and apoC-III (-0.11 mg/g protein; 95% CI: -0.18 to -0.026 mg/g protein) compared to the control diet, with weight loss being the essential mediator (proportions of mediation were 77.4% and 72.1% for triglycerides and apoC-III levels in HDL, respectively). CONCLUSIONS: In older adults with metabolic syndrome, an energy-restricted Mediterranean diet plus physical activity improved the HDL triglyceride metabolism compared with a nonrestrictive Mediterranean diet without physical activity. This trial is registered at isrctn.com as ISRCTN89898870.
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Soria-Florido, María TrinidadLund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)ma3310so
(author)
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Castañer, OlgaHospital del Mar Medical Research Institute,Carlos III Health Institute
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Lassale, CamilleCarlos III Health Institute,Hospital del Mar Medical Research Institute
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Salas-Salvadó, JordiRovira i Virgili University (URV),Carlos III Health Institute
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Martínez-González, Miguel ÁngelUniversity of Navarra,Carlos III Health Institute,Harvard University
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Subirana, IsaacHospital del Mar Medical Research Institute,Carlos III Health Institute
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Ros, EmilioHospital Clínic of Barcelona,Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS),Carlos III Health Institute
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Corella, DoloresUniversity of Valencia,Carlos III Health Institute
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Estruch, RamónHospital Clínic of Barcelona,Carlos III Health Institute,Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS)
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Tinahones, Francisco J.University of Malaga,Carlos III Health Institute
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Hernáez, ÁlvaroNorwegian Institute of Public Health,Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS),Carlos III Health Institute,Ramon Llull University
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Fitó, MontserratCarlos III Health Institute,Hospital del Mar Medical Research Institute
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Hospital del Mar Medical Research InstituteCarlos III Health Institute
(creator_code:org_t)
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In:The American journal of clinical nutrition: Elsevier BV114:5, s. 1666-16741938-32070002-9165
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Subirana, Isaac
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Ros, Emilio
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Hernáez, Álvaro
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Fitó, Montserrat
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