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Risk of subsequent ...
Risk of subsequent primary oral cancer in a cohort of 69,460 5-year survivors of childhood and adolescent cancer in Europe : the PanCareSurFup study
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- Sunguc, Ceren (författare)
- University of Birmingham
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- Hawkins, Michael M. (författare)
- University of Birmingham
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- Winter, David L. (författare)
- University of Birmingham
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- Dudley, Isabelle M. (författare)
- University of Birmingham
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- Heymer, Emma J. (författare)
- University of Birmingham
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- Teepen, Jop C. (författare)
- Princess Maxima Center for Pediatric Oncology/Hematology
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- Allodji, Rodrigue S. (författare)
- Centre for Research in Epidemiology and Population Health (CESP)
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Belle, Fabiën N. (författare)
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- Bagnasco, Francesca (författare)
- Gaslini Children's Hospital
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- Byrne, Julianne (författare)
- Boyne Research Institute
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- Bárdi, Edit (författare)
- St. Anna Children's Hospital
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- Ronckers, Cécile M. (författare)
- Carl von Ossietzky University of Oldenburg,Princess Maxima Center for Pediatric Oncology/Hematology
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- Haddy, Nadia (författare)
- Centre for Research in Epidemiology and Population Health (CESP)
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- Gudmundsdottir, Thorgerdur (författare)
- Danish Cancer Society,National University Hospital of Iceland
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- Garwicz, Stanislaw (författare)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Jankovic, Momcilo (författare)
- University of Milano-Bicocca
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- van der Pal, Helena J.H. (författare)
- Princess Maxima Center for Pediatric Oncology/Hematology
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- Mazić, Maja Česen (författare)
- University Children's Hospital, Ljubljana
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- Schindera, Christina (författare)
- University Children's Hospital, Basel,University of Bern
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- Grabow, Desiree (författare)
- Johannes-Gutenberg University Mainz
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- Maule, Milena M. (författare)
- University of Turin
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- Kaatsch, Peter (författare)
- Johannes-Gutenberg University Mainz
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- Kaiser, Melanie (författare)
- Johannes-Gutenberg University Mainz
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- Fresneau, Brice (författare)
- Institut Gustave Roussy,Centre for Research in Epidemiology and Population Health (CESP)
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- Michel, Gisela (författare)
- University of Lucerne
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- Skinner, Roderick (författare)
- University of Newcastle upon Tyne
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- Wiebe, Thomas (författare)
- Lund University,Lunds universitet,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,Late effects after childhood cancer treatment,Lund University Research Groups,Skåne University Hospital
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- Sacerdote, Carlotta (författare)
- University of Turin
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Jakab, Zsuzsanna (författare)
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- Gunnes, Maria Winther (författare)
- Norwegian Radium Hospital,Cancer Registry of Norway, Institute of Population-Based Cancer Research
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- Terenziani, Monica (författare)
- Istituto Nazionale dei Tumori
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- Winther, Jeanette F. (författare)
- Danish Cancer Society,Aarhus University Hospital
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- Lähteenmäki, Päivi M. (författare)
- Turku University Hospital
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- Zaletel, Lorna Zadravec (författare)
- Institute of Oncology, Ljubljana
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- Kuehni, Claudia E. (författare)
- University Children's Hospital Bern
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- Kremer, Leontien C. (författare)
- Princess Maxima Center for Pediatric Oncology/Hematology,Academic Medical Center of University of Amsterdam (AMC)
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- Haupt, Riccardo (författare)
- Gaslini Children's Hospital
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- de Vathaire, Florent (författare)
- Centre for Research in Epidemiology and Population Health (CESP)
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- Hjorth, Lars (författare)
- Lund University,Lunds universitet,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Late effects after childhood cancer treatment,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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- Reulen, Raoul C. (författare)
- University of Birmingham
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(creator_code:org_t)
- 2022-11-01
- 2023
- Engelska.
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Ingår i: British Journal of Cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 128:1, s. 80-90
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Background: Survivors of childhood cancer are at risk of subsequent primary malignant neoplasms (SPNs), but the risk for rarer types of SPNs, such as oral cancer, is uncertain. Previous studies included few oral SPNs, hence large-scale cohorts are required to identify groups at risks. Methods: The PanCareSurFup cohort includes 69,460 5-year survivors of childhood cancer across Europe. Risks of oral SPNs were defined by standardised incidence ratios (SIRs), absolute excess risks and cumulative incidence. Results: One hundred and forty-five oral SPNs (64 salivary gland, 38 tongue, 20 pharynx, 2 lip, and 21 other) were ascertained among 143 survivors. Survivors were at 5-fold risk of an oral SPN (95% CI: 4.4–5.6). Survivors of leukaemia were at greatest risk (SIR = 19.2; 95% CI: 14.6–25.2) followed by bone sarcoma (SIR = 6.4, 95% CI: 3.7–11.0), Hodgkin lymphoma (SIR = 6.2, 95% CI: 3.9–9.9) and soft-tissue sarcoma (SIR = 5.0, 95% CI: 3.0–8.5). Survivors treated with radiotherapy were at 33-fold risk of salivary gland SPNs (95% CI: 25.3–44.5), particularly Hodgkin lymphoma (SIR = 66.2, 95% CI: 43.6–100.5) and leukaemia (SIR = 50.5, 95% CI: 36.1–70.7) survivors. Survivors treated with chemotherapy had a substantially increased risk of a tongue SPN (SIR = 15.9, 95% CI: 10.6–23.7). Conclusions: Previous radiotherapy increases the risk of salivary gland SPNs considerably, while chemotherapy increases the risk of tongue SPNs substantially. Awareness of these risks among both health-care professionals and survivors could play a crucial role in detecting oral SPNs early.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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Sunguc, Ceren
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Hawkins, Michael ...
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Winter, David L.
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Dudley, Isabelle ...
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Heymer, Emma J.
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Teepen, Jop C.
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visa fler...
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Allodji, Rodrigu ...
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Belle, Fabiën N.
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Bagnasco, France ...
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Byrne, Julianne
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Bárdi, Edit
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Ronckers, Cécile ...
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Haddy, Nadia
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Gudmundsdottir, ...
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Garwicz, Stanisl ...
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Jankovic, Momcil ...
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van der Pal, Hel ...
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Mazić, Maja Čese ...
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Schindera, Chris ...
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Grabow, Desiree
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Maule, Milena M.
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Kaatsch, Peter
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Kaiser, Melanie
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Fresneau, Brice
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Michel, Gisela
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Skinner, Roderic ...
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Wiebe, Thomas
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Sacerdote, Carlo ...
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Jakab, Zsuzsanna
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Gunnes, Maria Wi ...
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Terenziani, Moni ...
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Winther, Jeanett ...
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Lähteenmäki, Päi ...
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Zaletel, Lorna Z ...
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Kuehni, Claudia ...
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Kremer, Leontien ...
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Haupt, Riccardo
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de Vathaire, Flo ...
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Hjorth, Lars
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Reulen, Raoul C.
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