id:"swepub:oai:lup.lub.lu.se:648c8bc2-67d8-432a-8f8a-cb3aae5da41b"
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- Persson, AnnetteLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine (författare)
Different assessments of immunohistochemically stained Ki-67 and hTERT in glioblastoma multiforme yield variable results: a study with reference to survival prognosis.
- Artikel/kapitelEngelska2008
Förlag, utgivningsår, omfång ...
- 2008
Nummerbeteckningar
- LIBRIS-ID:oai:lup.lub.lu.se:648c8bc2-67d8-432a-8f8a-cb3aae5da41b
- https://lup.lub.lu.se/record/1223683URI
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- Språk:engelska
- Sammanfattning på:engelska
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- OBJECTIVE: To investigate a marker of tumor proliferation, Ki-67, and telomerase expression in glioblastoma multiforme and to compare the results of different mainly quantitative assessments, in relation to age and survival rates. METHODS: Immunohistochemical stainings of Ki-67 and hTERT were evaluated in 39 formaldehyde-fixed, paraffin-embedded surgical samples of glioblastoma multiforme diagnosed during 2004, comprising all specimens with sufficient amount of vital tissue sent to the Department of Pathology during this year. Ki-67 counting and hTERT evaluation was assessed on whole tumor sections and on selected areas within each section. Age and length of survival were analyzed in relation to these parameters. RESULTS: We found that different methods of evaluating the stained sections yielded different results regarding Ki-67, but less marked differences for hTERT. With Ki-67 counting on whole sections (non-selected areas), we found a statistically significant correlation with length of survival. There was no corresponding information in the hTERT assessment. We could also confirm a significant inverse correlation between age and length of survival, as previously published. CONCLUSION: Our data demonstrate that different methods of Ki-67 evaluation may give markedly dissimilar results. The significant correlation found between survival and one but not with two other methods of Ki-67 assessment, implicate the value of standardized quantification methods. Our data indicate a possible prognostic use of immunohistochemical Ki-67 proliferation index in glioblastoma multiforme.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
- Ki-67 Antigen: biosynthesis
- Glioblastoma: pathology
- Glioblastoma: mortality
- Glioblastoma: metabolism
- Brain Neoplasms: pathology
- Brain Neoplasms: metabolism
- Brain Neoplasms: mortality
- Telomerase: biosynthesis
- Tumor Markers
- Biological: analysis
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Englund, ElisabetLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)pat-een (författare)
- TumörmikromiljöSektion I (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Clinical Neuropathology27:4, s. 224-2330722-5091
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- Clinical Neuropathology (Sök värdpublikationen i LIBRIS)
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