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Risk of cardiovascu...
Risk of cardiovascular disease among Nordic childhood cancer survivors with diabetes mellitus : A report from adult life after childhood cancer in Scandinavia
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- Winther, Jeanette F. (författare)
- Danish Cancer Society,Aarhus University
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- Bhatia, Smita (författare)
- University of Alabama
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- Cederkvist, Luise (författare)
- Danish Cancer Society
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- Gudmundsdottir, Thorgerdur (författare)
- Danish Cancer Society
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- Madanat-Harjuoja, Laura (författare)
- Finnish Cancer Registry
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- Tryggvadottir, Laufey (författare)
- Icelandic Cancer Registry,University of Iceland
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- Wesenberg, Finn (författare)
- University of Oslo,Oslo university hospital,Cancer Registry of Norway, Institute of Population-Based Cancer Research
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- Hasle, Henrik (författare)
- Aarhus University Hospital
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- Sällfors Holmqvist, Anna (författare)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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(creator_code:org_t)
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- 2018-10-11
- 2018
- Engelska.
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Ingår i: Cancer. - : Wiley. - 0008-543X. ; 124:22, s. 4393-4400
- Relaterad länk:
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http://dx.doi.org/10...
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https://acsjournals....
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Childhood cancer survivors have an increased risk of cardiovascular disease (CVD) and diabetes mellitus. Because diabetes is a potentially modifiable risk factor for CVD in the general population, it is important to understand how diabetes affects the risk of CVD among childhood cancer survivors. METHODS: This study examined the risk of CVD among survivors with diabetes and 142,742 population comparison subjects. From the national cancer registries of the 5 Nordic countries, 29,324 one-year survivors of cancer diagnosed before the age of 20 years between 1968 and 2008 were identified. Study subjects were linked to the national hospital registers. The cumulative incidence of CVD was determined with competing risk methods. A Cox proportional hazards model was used to estimate the effects of diabetes and cancer on the hazard of CVD. The interaction between diabetes and cancer was analyzed. RESULTS: Diabetes was diagnosed in 324 of the 29,324 one-year survivors, and CVD was diagnosed in 2108. The hazard of diabetes was 1.7 times higher among survivors than comparison subjects (hazard ratio [HR], 1.7; 95% confidence interval [CI], 1.5-1.9), whereas the HR of CVD was 3.6 (95% CI, 3.3-3.8) 1 to 15 years after the cancer diagnosis and 1.9 (95% CI, 1.8-2.0) after more than 15 years. Individuals with diabetes had a 2.4 times higher hazard of CVD (95% CI, 2.1-2.8) among both survivors and comparison subjects in comparison with individuals without diabetes. CONCLUSIONS: Childhood cancer survivors with diabetes have a markedly increased risk of CVD in comparison with survivors without diabetes. However, diabetes does not increase the risk of CVD more in survivors than the general population.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- cardiovascular disease
- cerebrovascular disease
- childhood cancer
- diabetes mellitus
- survivorship
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- art (ämneskategori)
- ref (ämneskategori)
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