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  • Cadrin-Tourigny, JuliaJohns Hopkins Hospital,Montreal Heart Institute,Johns Hopkins Univ Hosp, MD 21287 USA; Univ Montreal, Canada (author)

A new prediction model for ventricular arrhythmias in arrhythmogenic right ventricular cardiomyopathy

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2019-03-27
  • Oxford University Press (OUP),2019
  • 9 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:64991361-5d8a-43ec-90a3-a9798805f4d7
  • https://lup.lub.lu.se/record/64991361-5d8a-43ec-90a3-a9798805f4d7URI
  • https://doi.org/10.1093/eurheartj/ehz103DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-161418URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Funding Agencies|Canadian Heart Rhythm Society George Mines Traveling Fellowship; Montreal Heart Institute Foundation Bal du Coeur bursary; Fondation LeducqLeducq Foundation [16 CVD 02]; Dutch Heart FoundationNetherlands Heart Foundation [2015T058]; Netherlands Organisation for Scientific ResearchNetherlands Organization for Scientific Research (NWO) [040.11.586]; Netherlands Heart Institute [06901]; Swiss National Science FoundationSwiss National Science Foundation (SNSF) [320030_160327]; UMC Utrecht 2017 Alexandre Suerman Stipend; UMC Utrecht Fellowship Clinical Research Talent; European Unions Horizon 2020 research and innovation program under the ERA-NET Co-fund action [680969]; Dr Francis P. Chiaramonte Private Foundation; Leyla Erkan Family Fund for ARVD Research; Dr Satish, Rupal, and Robin Shah ARVD Fund at Johns Hopkins; Bogle Foundation; Healing Hearts Foundation; Peter French Memorial Foundation; Wilmerding Endowments; Georg und Bertha Schwyzer-Winiker Foundation; Baugarten Foundation; Swiss Heart Foundation; Leonie-Wild Foundation; Marvin and Philippa Carsley Chair of Medicine; UCL Hospitals NIHR Biomedical Research Centre
  • AIMS: Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVC) is characterized by ventricular arrhythmias (VAs) and sudden cardiac death (SCD). We aimed to develop a model for individualized prediction of incident VA/SCD in ARVC patients. METHODS AND RESULTS: Five hundred and twenty-eight patients with a definite diagnosis and no history of sustained VAs/SCD at baseline, aged 38.2 ± 15.5 years, 44.7% male, were enrolled from five registries in North America and Europe. Over 4.83 (interquartile range 2.44-9.33) years of follow-up, 146 (27.7%) experienced sustained VA, defined as SCD, aborted SCD, sustained ventricular tachycardia, or appropriate implantable cardioverter-defibrillator (ICD) therapy. A prediction model estimating annual VA risk was developed using Cox regression with internal validation. Eight potential predictors were pre-specified: age, sex, cardiac syncope in the prior 6 months, non-sustained ventricular tachycardia, number of premature ventricular complexes in 24 h, number of leads with T-wave inversion, and right and left ventricular ejection fractions (LVEFs). All except LVEF were retained in the final model. The model accurately distinguished patients with and without events, with an optimism-corrected C-index of 0.77 [95% confidence interval (CI) 0.73-0.81] and minimal over-optimism [calibration slope of 0.93 (95% CI 0.92-0.95)]. By decision curve analysis, the clinical benefit of the model was superior to a current consensus-based ICD placement algorithm with a 20.6% reduction of ICD placements with the same proportion of protected patients (P < 0.001). CONCLUSION: Using the largest cohort of patients with ARVC and no prior VA, a prediction model using readily available clinical parameters was devised to estimate VA risk and guide decisions regarding primary prevention ICDs (www.arvcrisk.com).

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Bosman, Laurens P.University Medical Center Utrecht,Interuniversity Cardiology Institute of the Netherlands,Netherlands Heart Inst, Netherlands; Univ Utrecht, Netherlands (author)
  • Nozza, AnnaUniversity Of Quebec In Montreal,Univ Montreal, Canada (author)
  • Wang, WeijiaJohns Hopkins Hospital,Johns Hopkins Univ Hosp, MD 21287 USA,Netherlands Heart Inst, Netherlands; Univ Utrecht, Netherlands; UCL, England (author)
  • Tadros, RafikMontreal Heart Institute,Univ Montreal, Canada (author)
  • Bhonsale, AdityaJohns Hopkins Hospital,Johns Hopkins Univ Hosp, MD 21287 USA (author)
  • Bourfiss, MimountUniversity Medical Center Utrecht,Univ Utrecht, Netherlands (author)
  • Fortier, AnnikUniversity Of Quebec In Montreal,Univ Montreal, Canada (author)
  • Lie, Øyvind H.University of Oslo,Oslo university hospital,Oslo Univ Hosp, Norway; Univ Oslo, Norway (author)
  • Saguner, Ardan M.University Hospital of Zurich,Univ Heart Ctr Zurich, Switzerland (author)
  • Svensson, AnneliLinköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US,Netherlands Heart Inst, Netherlands; Univ Utrecht, Netherlands(Swepub:liu)annsv58 (author)
  • Andorin, AntoineMontreal Heart Institute,Univ Montreal, Canada,Univ Amsterdam Heart Ctr, AZ 1105 USA,Johns Hopkins Univ Hosp, MD 21287 USA (author)
  • Tichnell, CrystalJohns Hopkins Hospital,Johns Hopkins Univ Hosp, MD 21287 USA (author)
  • Murray, BrittneyJohns Hopkins Hospital,Johns Hopkins Univ Hosp, MD 21287 USA (author)
  • Zeppenfeld, KatjaLeiden University Medical Centre,Leiden Univ, Netherlands (author)
  • van den Berg, Maarten P.University Medical Center Groningen,Univ Med Ctr Groningen, Netherlands (author)
  • Asselbergs, Folkert W.University College London,University Medical Center Utrecht (author)
  • Wilde, Arthur A.M.University of Amsterdam (author)
  • Krahn, Andrew D.University of British Columbia,Univ British Columbia, Canada (author)
  • Talajic, MarioMontreal Heart Institute,Univ Montreal, Canada (author)
  • Rivard, LenaMontreal Heart Institute,Univ Montreal, Canada (author)
  • Chelko, StephenJohns Hopkins Hospital,Johns Hopkins Univ Hosp, MD 21287 USA (author)
  • Zimmerman, Stefan L.Johns Hopkins Hospital,Johns Hopkins Univ Hosp, MD 21287 USA (author)
  • Kamel, Ihab R.Johns Hopkins Hospital,Johns Hopkins Univ Hosp, MD 21287 USA (author)
  • Crosson, Jane E.Johns Hopkins Hospital,Johns Hopkins Univ Hosp, MD 21287 USA (author)
  • Judge, Daniel P.Johns Hopkins Hospital,Johns Hopkins Univ Hosp, MD 21287 USA (author)
  • Yap, Sing ChienErasmus University Medical Center,Erasmus MC, Netherlands (author)
  • van der Heijden, Jeroen F.University Medical Center Utrecht,Univ Utrecht, Netherlands (author)
  • Tandri, HarikrishnaJohns Hopkins Hospital,Johns Hopkins Univ Hosp, MD 21287 USA (author)
  • Jongbloed, Jan D.H.University Medical Center Groningen,Univ Groningen, Netherlands (author)
  • Guertin, Marie ClaudeUniversity Of Quebec In Montreal,Univ Montreal, Canada (author)
  • van Tintelen, J. PeterAcademic Medical Center of University of Amsterdam (AMC),Interuniversity Cardiology Institute of the Netherlands,Netherlands Heart Inst, Netherlands; Univ Amsterdam, Netherlands (author)
  • Platonov, Pyotr G.Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Electrocardiology Research Group - CIEL,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Lund Univ Hosptial, Sweden(Swepub:lu)kard-ppl (author)
  • Duru, FiratUniversity Hospital of Zurich,Univ Heart Ctr Zurich, Switzerland (author)
  • Haugaa, Kristina H.University of Oslo,Oslo university hospital,Oslo Univ Hosp, Norway; Univ Oslo, Norway (author)
  • Khairy, PaulUniversity Of Quebec In Montreal,Univ Montreal, Canada (author)
  • Hauer, Richard N.W.University Medical Center Utrecht (author)
  • Calkins, HughJohns Hopkins Hospital,Johns Hopkins Univ Hosp, MD 21287 USA (author)
  • Te Riele, Anneline S.J.M.University Medical Center Utrecht (author)
  • James, Cynthia A.Johns Hopkins Hospital (author)
  • Johns Hopkins HospitalMontreal Heart Institute (creator_code:org_t)

Related titles

  • In:European Heart Journal: Oxford University Press (OUP)40:23, s. 1850-18581522-96450195-668X

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