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A new prediction mo...
A new prediction model for ventricular arrhythmias in arrhythmogenic right ventricular cardiomyopathy
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- Cadrin-Tourigny, Julia (author)
- Johns Hopkins Hospital,Montreal Heart Institute,Johns Hopkins Univ Hosp, MD 21287 USA; Univ Montreal, Canada
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- Bosman, Laurens P. (author)
- University Medical Center Utrecht,Interuniversity Cardiology Institute of the Netherlands,Netherlands Heart Inst, Netherlands; Univ Utrecht, Netherlands
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- Nozza, Anna (author)
- University Of Quebec In Montreal,Univ Montreal, Canada
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- Wang, Weijia (author)
- Johns Hopkins Hospital,Johns Hopkins Univ Hosp, MD 21287 USA,Netherlands Heart Inst, Netherlands; Univ Utrecht, Netherlands; UCL, England
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- Tadros, Rafik (author)
- Montreal Heart Institute,Univ Montreal, Canada
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- Bhonsale, Aditya (author)
- Johns Hopkins Hospital,Johns Hopkins Univ Hosp, MD 21287 USA
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- Bourfiss, Mimount (author)
- University Medical Center Utrecht,Univ Utrecht, Netherlands
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- Fortier, Annik (author)
- University Of Quebec In Montreal,Univ Montreal, Canada
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- Lie, Øyvind H. (author)
- University of Oslo,Oslo university hospital,Oslo Univ Hosp, Norway; Univ Oslo, Norway
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- Saguner, Ardan M. (author)
- University Hospital of Zurich,Univ Heart Ctr Zurich, Switzerland
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- Svensson, Anneli (author)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US,Netherlands Heart Inst, Netherlands; Univ Utrecht, Netherlands
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- Andorin, Antoine (author)
- Montreal Heart Institute,Univ Montreal, Canada,Univ Amsterdam Heart Ctr, AZ 1105 USA,Johns Hopkins Univ Hosp, MD 21287 USA
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- Tichnell, Crystal (author)
- Johns Hopkins Hospital,Johns Hopkins Univ Hosp, MD 21287 USA
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- Murray, Brittney (author)
- Johns Hopkins Hospital,Johns Hopkins Univ Hosp, MD 21287 USA
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- Zeppenfeld, Katja (author)
- Leiden University Medical Centre,Leiden Univ, Netherlands
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- van den Berg, Maarten P. (author)
- University Medical Center Groningen,Univ Med Ctr Groningen, Netherlands
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- Asselbergs, Folkert W. (author)
- University College London,University Medical Center Utrecht
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- Wilde, Arthur A.M. (author)
- University of Amsterdam
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- Krahn, Andrew D. (author)
- University of British Columbia,Univ British Columbia, Canada
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- Talajic, Mario (author)
- Montreal Heart Institute,Univ Montreal, Canada
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- Rivard, Lena (author)
- Montreal Heart Institute,Univ Montreal, Canada
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- Chelko, Stephen (author)
- Johns Hopkins Hospital,Johns Hopkins Univ Hosp, MD 21287 USA
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- Zimmerman, Stefan L. (author)
- Johns Hopkins Hospital,Johns Hopkins Univ Hosp, MD 21287 USA
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- Kamel, Ihab R. (author)
- Johns Hopkins Hospital,Johns Hopkins Univ Hosp, MD 21287 USA
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- Crosson, Jane E. (author)
- Johns Hopkins Hospital,Johns Hopkins Univ Hosp, MD 21287 USA
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- Judge, Daniel P. (author)
- Johns Hopkins Hospital,Johns Hopkins Univ Hosp, MD 21287 USA
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- Yap, Sing Chien (author)
- Erasmus University Medical Center,Erasmus MC, Netherlands
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- van der Heijden, Jeroen F. (author)
- University Medical Center Utrecht,Univ Utrecht, Netherlands
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- Tandri, Harikrishna (author)
- Johns Hopkins Hospital,Johns Hopkins Univ Hosp, MD 21287 USA
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- Jongbloed, Jan D.H. (author)
- University Medical Center Groningen,Univ Groningen, Netherlands
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- Guertin, Marie Claude (author)
- University Of Quebec In Montreal,Univ Montreal, Canada
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- van Tintelen, J. Peter (author)
- Academic Medical Center of University of Amsterdam (AMC),Interuniversity Cardiology Institute of the Netherlands,Netherlands Heart Inst, Netherlands; Univ Amsterdam, Netherlands
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- Platonov, Pyotr G. (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Electrocardiology Research Group - CIEL,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Lund Univ Hosptial, Sweden
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- Duru, Firat (author)
- University Hospital of Zurich,Univ Heart Ctr Zurich, Switzerland
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- Haugaa, Kristina H. (author)
- University of Oslo,Oslo university hospital,Oslo Univ Hosp, Norway; Univ Oslo, Norway
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- Khairy, Paul (author)
- University Of Quebec In Montreal,Univ Montreal, Canada
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- Hauer, Richard N.W. (author)
- University Medical Center Utrecht
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- Calkins, Hugh (author)
- Johns Hopkins Hospital,Johns Hopkins Univ Hosp, MD 21287 USA
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- Te Riele, Anneline S.J.M. (author)
- University Medical Center Utrecht
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- James, Cynthia A. (author)
- Johns Hopkins Hospital
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(creator_code:org_t)
- 2019-03-27
- 2019
- English 9 s.
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In: European Heart Journal. - : Oxford University Press (OUP). - 1522-9645 .- 0195-668X. ; 40:23, s. 1850-1858
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- AIMS: Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVC) is characterized by ventricular arrhythmias (VAs) and sudden cardiac death (SCD). We aimed to develop a model for individualized prediction of incident VA/SCD in ARVC patients. METHODS AND RESULTS: Five hundred and twenty-eight patients with a definite diagnosis and no history of sustained VAs/SCD at baseline, aged 38.2 ± 15.5 years, 44.7% male, were enrolled from five registries in North America and Europe. Over 4.83 (interquartile range 2.44-9.33) years of follow-up, 146 (27.7%) experienced sustained VA, defined as SCD, aborted SCD, sustained ventricular tachycardia, or appropriate implantable cardioverter-defibrillator (ICD) therapy. A prediction model estimating annual VA risk was developed using Cox regression with internal validation. Eight potential predictors were pre-specified: age, sex, cardiac syncope in the prior 6 months, non-sustained ventricular tachycardia, number of premature ventricular complexes in 24 h, number of leads with T-wave inversion, and right and left ventricular ejection fractions (LVEFs). All except LVEF were retained in the final model. The model accurately distinguished patients with and without events, with an optimism-corrected C-index of 0.77 [95% confidence interval (CI) 0.73-0.81] and minimal over-optimism [calibration slope of 0.93 (95% CI 0.92-0.95)]. By decision curve analysis, the clinical benefit of the model was superior to a current consensus-based ICD placement algorithm with a 20.6% reduction of ICD placements with the same proportion of protected patients (P < 0.001). CONCLUSION: Using the largest cohort of patients with ARVC and no prior VA, a prediction model using readily available clinical parameters was devised to estimate VA risk and guide decisions regarding primary prevention ICDs (www.arvcrisk.com).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Arrhythmogenic right ventricular cardiomyopathy
- Implantable cardioverter-defibrillators
- Sudden cardiac death
- Ventricular arrhythmias
- Arrhythmogenic right ventricular cardiomyopathy; Implantable cardioverter-defibrillators; Sudden cardiac death; Ventricular arrhythmias
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Cadrin-Tourigny, ...
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Bosman, Laurens ...
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Nozza, Anna
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Wang, Weijia
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Tadros, Rafik
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Bhonsale, Aditya
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show more...
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Bourfiss, Mimoun ...
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Fortier, Annik
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Lie, Øyvind H.
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Saguner, Ardan M ...
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Svensson, Anneli
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Andorin, Antoine
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Tichnell, Crysta ...
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Murray, Brittney
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Zeppenfeld, Katj ...
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van den Berg, Ma ...
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Asselbergs, Folk ...
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Wilde, Arthur A. ...
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Krahn, Andrew D.
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Talajic, Mario
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Rivard, Lena
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Chelko, Stephen
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Zimmerman, Stefa ...
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Kamel, Ihab R.
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Crosson, Jane E.
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Judge, Daniel P.
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Yap, Sing Chien
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van der Heijden, ...
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Tandri, Harikris ...
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Jongbloed, Jan D ...
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Guertin, Marie C ...
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van Tintelen, J. ...
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Platonov, Pyotr ...
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Duru, Firat
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Haugaa, Kristina ...
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Khairy, Paul
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Hauer, Richard N ...
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Calkins, Hugh
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Te Riele, Anneli ...
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James, Cynthia A ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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European Heart J ...
- By the university
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Lund University
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Linköping University