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Sökning: WFRF:(Jensen Johan Kjellberg) > Dietary fatty acids...

Dietary fatty acids modulate oxidative stress response to air pollution but not to infection

Ziegler, Ann Kathrin (författare)
Lund University,Lunds universitet,Molekylär ekologi och evolution,Forskargrupper vid Lunds universitet,Evolutionär ekologi och infektionsbiologi,Avdelningar vid Biologiska institutionen,Biologiska institutionen,Naturvetenskapliga fakulteten,Molecular Ecology and Evolution Lab,Lund University Research Groups,Evolutionary ecology and infection biology,Sections at the Department of Biology,Department of Biology,Faculty of Science
Jensen, Johan Kjellberg (författare)
Lund University,Lunds universitet,Centrum för miljö- och klimatvetenskap (CEC),Naturvetenskapliga fakulteten,Biodiversitet och evolution,Avdelningar vid Biologiska institutionen,Biologiska institutionen,Centre for Environmental and Climate Science (CEC),Faculty of Science,Biodiversity and evolution,Sections at the Department of Biology,Department of Biology
Jiménez-Gallardo, Lucía (författare)
Complutense University of Madrid
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Rissler, Jenny (författare)
Lund University,Lunds universitet,NanoLund: Centre for Nanoscience,Annan verksamhet, LTH,Lunds Tekniska Högskola,Ergonomi och aerosolteknologi,Institutionen för designvetenskaper,Institutioner vid LTH,MERGE: ModElling the Regional and Global Earth system,Centrum för miljö- och klimatvetenskap (CEC),Naturvetenskapliga fakulteten,LTH profilområde: Aerosoler,LTH profilområden,LTH profilområde: Nanovetenskap och halvledarteknologi,LU profilområde: Ljus och material,Lunds universitets profilområden,Other operations, LTH,Faculty of Engineering, LTH,Ergonomics and Aerosol Technology,Department of Design Sciences,Departments at LTH,Faculty of Engineering, LTH,Centre for Environmental and Climate Science (CEC),Faculty of Science,LTH Profile Area: Aerosols,LTH Profile areas,Faculty of Engineering, LTH,LTH Profile Area: Nanoscience and Semiconductor Technology,Faculty of Engineering, LTH,LU Profile Area: Light and Materials,Lund University Profile areas,Research Institutes of Sweden (RISE)
Gudmundsson, Anders (författare)
Lund University,Lunds universitet,NanoLund: Centre for Nanoscience,Annan verksamhet, LTH,Lunds Tekniska Högskola,Ergonomi och aerosolteknologi,Institutionen för designvetenskaper,Institutioner vid LTH,MERGE: ModElling the Regional and Global Earth system,Centrum för miljö- och klimatvetenskap (CEC),Naturvetenskapliga fakulteten,LTH profilområde: Aerosoler,LTH profilområden,LTH profilområde: Nanovetenskap och halvledarteknologi,LU profilområde: Ljus och material,Lunds universitets profilområden,Other operations, LTH,Faculty of Engineering, LTH,Ergonomics and Aerosol Technology,Department of Design Sciences,Departments at LTH,Faculty of Engineering, LTH,Centre for Environmental and Climate Science (CEC),Faculty of Science,LTH Profile Area: Aerosols,LTH Profile areas,Faculty of Engineering, LTH,LTH Profile Area: Nanoscience and Semiconductor Technology,Faculty of Engineering, LTH,LU Profile Area: Light and Materials,Lund University Profile areas
Nilsson, Jan Åke (författare)
Lund University,Lunds universitet,Ekologisk och evolutionär fysiologi,Forskargrupper vid Lunds universitet,Evolutionär ekologi och infektionsbiologi,Avdelningar vid Biologiska institutionen,Biologiska institutionen,Naturvetenskapliga fakulteten,Ecological and Evolutionary Physiology,Lund University Research Groups,Evolutionary ecology and infection biology,Sections at the Department of Biology,Department of Biology,Faculty of Science
Isaksson, Caroline (författare)
Lund University,Lunds universitet,BECC: Biodiversity and Ecosystem services in a Changing Climate,Centrum för miljö- och klimatvetenskap (CEC),Naturvetenskapliga fakulteten,LTH profilområde: Aerosoler,LTH profilområden,Lunds Tekniska Högskola,Evolutionär ekologi och infektionsbiologi,Avdelningar vid Biologiska institutionen,Biologiska institutionen,Centre for Environmental and Climate Science (CEC),Faculty of Science,LTH Profile Area: Aerosols,LTH Profile areas,Faculty of Engineering, LTH,Evolutionary ecology and infection biology,Sections at the Department of Biology,Department of Biology
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 (creator_code:org_t)
2024
2024
Engelska 13 s.
Ingår i: Frontiers in Physiology. - 1664-042X. ; 15
Relaterad länk:
http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
https://doi.org/10.3...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Anthropogenic changes to the environment expose wildlife to many pollutants. Among these, tropospheric ozone is of global concern and a highly potent pro-oxidant. In addition, human activities include several other implications for wildlife, e.g., changed food availability and changed distribution of pathogens in cities. These co-occurring habitat changes may interact, thereby modulating the physiological responses and costs related to anthropogenic change. For instance, many food items associated with humans (e.g., food waste and feeders for wild birds) contain relatively more ω6-than ω3-polyunsaturated fatty acids (PUFAs). Metabolites derived from ω6-PUFAs can enhance inflammation and oxidative stress towards a stimulus, whereas the opposite response is linked to ω3-derived metabolites. Hence, we hypothesized that differential intake of ω6-and ω3-PUFAs modulates the oxidative stress state of birds and thereby affects the responses towards pro-oxidants. To test this, we manipulated dietary ω6:ω3 ratios and ozone levels in a full-factorial experiment using captive zebra finches (Taeniopygia guttata). Additionally, we simulated an infection, thereby also triggering the immune system’s adaptive pro-oxidant release (i.e., oxidative burst), by injecting lipopolysaccharide. Under normal air conditions, the ω3-diet birds had a lower antioxidant ratio (GSH/GSSG ratio) compared to the ω6-diet birds. When exposed to ozone, however, the diet effect disappeared. Instead, ozone exposure overall reduced the total concentration of the key antioxidant glutathione (tGSH). Moreover, the birds on the ω6-rich diet had an overall higher antioxidant capacity (OXY) compared to birds fed a ω3-rich diet. Interestingly, only the immune challenge increased oxidative damage, suggesting the oxidative burst of the immune system overrides the other pro-oxidative processes, including diet. Taken together, our results show that ozone, dietary PUFAs, and infection all affect the redox-system, but in different ways, suggesting that the underlying responses are decoupled despite that they all increase pro-oxidant exposure or generation. Despite lack of apparent cumulative effect in the independent biomarkers, the combined single effects could together reduce overall cellular functioning and efficiency over time in wild birds exposed to pathogens, ozone, and anthropogenic food sources.

Ämnesord

NATURVETENSKAP  -- Biologi -- Zoologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Zoology (hsv//eng)
NATURVETENSKAP  -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
NATURAL SCIENCES  -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)

Nyckelord

antioxidants
avian
immune function
multiple stressors
nutrition
tropospheric ozone

Publikations- och innehållstyp

art (ämneskategori)
ref (ämneskategori)

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