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An international ne...
An international network (PlaNet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy
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- Brownbill, Paul (author)
- University of Manchester,Manchester University NHS Foundation Trust
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- Chernyavsky, Igor (author)
- University of Manchester
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- Bottalico, Barbara (author)
- Lund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Desoye, Gernot (author)
- Medical University of Graz
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- Hansson, Stefan (author)
- Lund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Kenna, Gerry (author)
- Safer Medicines Trust
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- Knudsen, Lisbeth E. (author)
- University of Copenhagen
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- Markert, Udo R. (author)
- Friedrich Schiller University Jena
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- Powles-Glover, Nicola (author)
- AstraZeneca, Sweden
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- Schneider, Henning (author)
- University of Bern
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- Leach, Lopa (author)
- University of Nottingham
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English 12 s.
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In: Reproductive Toxicology. - : Elsevier BV. - 0890-6238. ; 64, s. 191-202
- Related links:
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http://dx.doi.org/10...
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https://nottingham-r...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The human placenta is a critical life-support system that nourishes and protects a rapidly growing fetus; a unique organ, species specific in structure and function. We consider the pressing challenge of providing additional advice on the safety of prescription medicines and environmental exposures in pregnancy and how ex vivo and in vitro human placental models might be advanced to reproducible human placental test systems (HPTSs), refining a weight of evidence to the guidance given around compound risk assessment during pregnancy. The placental pharmacokinetics of xenobiotic transfer, dysregulated placental function in pregnancy-related pathologies and influx/efflux transporter polymorphisms are a few caveats that could be addressed by HPTSs, not the specific focus of current mammalian reproductive toxicology systems. An international consortium, “PlaNet”, will bridge academia, industry and regulators to consider screen ability and standardisation issues surrounding these models, with proven reproducibility for introduction into industrial and clinical practice.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- 3Rs
- Human placenta
- PlaNet
- Reproductive toxicology testing
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Brownbill, Paul
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Chernyavsky, Igo ...
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Bottalico, Barba ...
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Desoye, Gernot
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Hansson, Stefan
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Kenna, Gerry
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show more...
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Knudsen, Lisbeth ...
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Markert, Udo R.
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Powles-Glover, N ...
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Schneider, Henni ...
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Leach, Lopa
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmacology and ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
- Articles in the publication
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Reproductive Tox ...
- By the university
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Lund University