Bivalent polyether ionophores : Synthesis and biological evaluation of C2-symmetric salinomycin dimers

• Efficient methods for the synthesis of C2-symmetric dimers of salinomycin joined at either the C1 or C20 positions are reported. Similarly to the native structure, the C20-O-terephthalate dimer displayed activity in the low μM range against a series of cancer cell lines, while dimers joined at the C1 position were essentially inactive.

Ämnesord

NATURVETENSKAP  -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)

NATURAL SCIENCES  -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)

Nyckelord

Anti-proliferative activity

Glaser-type coupling reaction

Ionophore antibiotics

Multivalent structures

SRB assay

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