Search: (WFRF:(Isaksson S.))
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von Willebrand fact...
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Karpman, DLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Pediatrisk nefrologi,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Pediatric Nephrology,Lund University Research Groups,The Children's Hospital of Philadelphia
(author)
von Willebrand factor mediates increased platelet retention in recurrent thrombotic thrombocytopenic purpura
- Article/chapterEnglish1997
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Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:65c9f398-1e7c-4115-a7bd-371ee9aca477
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https://lup.lub.lu.se/record/65c9f398-1e7c-4115-a7bd-371ee9aca477URI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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The plasma cryoprecipitate of two brothers with recurrent thrombotic thrombocytopenic purpura (TTP) was previously found to mediate increased platelet retention and contain ultra-large von Willebrand factor (vWF) multimers during remissions. We conducted this study to examine if vWF is involved in the increased platelet retention in TTP. Platelet retention decreased when the patients' plasma was incubated with a monoclonal antibody directed to the vWF epitope which interacts with the platelet receptor glycoprotein Ib or when incubated with a Fab-fragment directed to the platelet receptor glycoprotein IIb/IIIa. Replacement of patient vWF with an equivalent concentration of a factor VIII/vWF concentrate containing no ultra-large vWF multimers was accompanied by a normalization of platelet retention. These results indicate that vWF is involved in the increased platelet retention. Analysis of polymorphic markers in the vWF gene demonstrated that a recessive mutation in this gene is unlikely.
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Lethagen, SSkåne University Hospital(Swepub:lu)medf-sle
(author)
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Kristoffersson, AnneLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-ak3
(author)
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Isaksson, C.Lund University
(author)
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Holmberg, LarsLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)pedi-lho
(author)
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Pediatrik, LundSektion V
(creator_code:org_t)
Related titles
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In:Thrombosis and Haemostasis78:6, s. 62-14560340-6245
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