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A novel partial vol...
A novel partial volume correction method for accurate quantification of [18F] flortaucipir in the hippocampus
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- Wolters, Emma E. (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Golla, Sandeep S.V. (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Timmers, Tessa (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Ossenkoppele, Rik (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Amsterdam UMC - Vrije Universiteit Amsterdam
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- van der Weijden, Chris W.J. (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Scheltens, Philip (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Schwarte, Lothar (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Schuit, Robert C. (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Windhorst, Albert D. (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Barkhof, Frederik (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam,University College London
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- Yaqub, Maqsood (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Lammertsma, Adriaan A. (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Boellaard, Ronald (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- van Berckel, Bart N.M. (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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(creator_code:org_t)
- 2018-08-15
- 2018
- English.
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In: EJNMMI Research. - : Springer Science and Business Media LLC. - 2191-219X. ; 8
- Related links:
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http://dx.doi.org/10... (free)
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https://ejnmmires.sp...
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https://doi.org/10.1...
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Abstract
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- Background: Off-target binding in the choroid plexus (CP) may cause spill-in of the tau PET tracer [18F] flortaucipir into the adjacent hippocampus region. The impact of this spill-in on hippocampal uptake was assessed using a novel partial volume correction method (PVC). Methods: PVC was performed on 20 [18F] flortaucipir dynamic PET scans (10 probable AD and 10 controls). Volumes of interest (VOIs) were defined for both hippocampus and CP. The correlation between hippocampal and CP distribution volume (VT), with and without PVC, was determined. Both anatomically defined and eroded VOIs were used. Results: For controls, the correlation between hippocampal and CP VT was significantly reduced after using PVC along with an eroded VOI (r2 = 0.59, slope = 0.80 versus r2 = 0.15, slope = 0.15; difference: p < 0.05). The same was true for AD patients (p < 0.05). Conclusion: PVC together with an optimized hippocampal VOI resulted in effective reduction of CP spill-in and improved accuracy of hippocampal VT.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
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- By the author/editor
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Wolters, Emma E.
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Golla, Sandeep S ...
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Timmers, Tessa
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Ossenkoppele, Ri ...
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van der Weijden, ...
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Scheltens, Phili ...
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Schwarte, Lothar
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Schuit, Robert C ...
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Windhorst, Alber ...
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Barkhof, Frederi ...
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Yaqub, Maqsood
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Lammertsma, Adri ...
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Boellaard, Ronal ...
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van Berckel, Bar ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Radiology Nuclea ...
- Articles in the publication
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EJNMMI Research
- By the university
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Lund University