WFRF:(Jia Qiyu)
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- Zhang, ShunmingXi’an Medical University,Xi'an Jiaotong University (author)
Adherence to a healthy lifestyle including sleep and sedentary behaviors and risk of metabolic dysfunction-associated steatotic liver disease in Chinese adults
- Article/chapterEnglish2024
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- 2024
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- LIBRIS-ID:oai:lup.lub.lu.se:66bc7852-4891-4067-b2fe-cca3a1f073e3
- https://lup.lub.lu.se/record/66bc7852-4891-4067-b2fe-cca3a1f073e3URI
- https://doi.org/10.1016/j.ypmed.2024.107971DOI
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- Language:English
- Summary in:English
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- SwePubSwePub
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- Objective: Various lifestyle factors including smoking, alcohol, physical activity, sedentary behavior, diet quality, sleep behavior, and overweight have been related to metabolic dysfunction-associated steatotic liver disease (MASLD); however, their joint impact on risk of MASLD is not well known. We prospectively investigated the association between a combination of lifestyle factors and risk of MASLD. Methods: This prospective cohort study included 13,303 participants (mean age: 39.1 ± 11.3 years, female: 60.1%) in China. A novel healthy lifestyle score was created combining seven healthy factors: not smoking, no alcohol intake, regular physical activity, short sedentary time, healthy diet, healthy sleep, and healthy weight. Incident MASLD cases were ascertained annually by liver ultrasound and cardiometabolic risk factors. Multivariable Cox proportional hazards regression models were used to estimate the association of healthy lifestyle score with risk of MASLD. Results: Within 48,036 person-years of follow-up, 2823 participants developed MASLD. After adjusting for age, sex, education, occupation, household income, personal and family history of disease, and total energy intake, compared with participants with 0–2 healthy lifestyle factors, the multivariable hazard ratios (95% confidence interval) of MASLD were 0.81 (0.73, 0.89), 0.67 (0.61, 0.75), and 0.55 (0.49, 0.62) for healthy lifestyle score of 3, 4, and 5–7, respectively (P for trend <0.0001). Such associations were consistent across subgroup and sensitivity analyses. Conclusion: Our results indicate that a higher healthy lifestyle score is associated with a lower risk of MASLD.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Health Sciences Public Health, Global Health, Social Medicine and Epidemiology hsv//eng
- Cohort studies
- Epidemiology
- Lifestyle
- Metabolic dysfunction-associated steatotic liver disease
Added entries (persons, corporate bodies, meetings, titles ...)
- Huo, ZhenyuNorth China University of Science and Technology (NCUST) (author)
- Borné, YanLund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups(Swepub:lu)med-boy (author)
- Meng, GeTianjin Medical University (author)
- Zhang, QingTianjin Medical University (author)
- Liu, LiTianjin Medical University (author)
- Wu, HongmeiTianjin Medical University (author)
- Gu, Yeqing (author)
- Sun, ShaomeiTianjin Medical University (author)
- Wang, XingTianjin Medical University (author)
- Zhou, MingTianjin Medical University (author)
- Jia, QiyuTianjin Medical University (author)
- Song, KunTianjin Medical University (author)
- Ma, LeXi’an Medical University,Xi'an Jiaotong University (author)
- Qi, LuHarvard University,Tulane University (author)
- Niu, KaijunTianjin Medical University (author)
- Xi’an Medical UniversityXi'an Jiaotong University (creator_code:org_t)
Related titles
- In:Preventive Medicine1840091-7435
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