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Tumor-directed immu...
Tumor-directed immunotherapy can generate tumor-specific T cell responses through localized co-stimulation
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- Ellmark, Peter (författare)
- Lund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH,Alligator Biosciences AB,Alligator Biosci AB, S-22363 Lund, Sweden.;Lund Univ, Dept Immunotechnol, Lund, Sweden.
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- Mangsbo, Sara M. (författare)
- Uppsala universitet,Uppsala University,Klinisk immunologi
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- Furebring, Christina (författare)
- Alligator Biosciences AB,Alligator Biosci AB, S-22363 Lund, Sweden.
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- Norlén, Per (författare)
- Alligator Biosciences AB,Alligator Biosci AB, S-22363 Lund, Sweden.
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- Tötterman, Thomas (författare)
- Uppsala universitet,Uppsala University,Klinisk immunologi
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(creator_code:org_t)
- 2016-10-06
- 2017
- Engelska 7 s.
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Ingår i: Cancer Immunology and Immunotherapy. - : Springer Science and Business Media LLC. - 0340-7004 .- 1432-0851. ; 66:1, s. 1-7
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://link.springe...
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- The most important goals for the field of immuno-oncology are to improve the response rate and increase the number of tumor indications that respond to immunotherapy, without increasing adverse side effects. One approach to achieve these goals is to use tumor-directed immunotherapy, i.e., to focus the immune activation to the most relevant part of the immune system. This may improve anti-tumor efficacy as well as reduce immune-related adverse events. Tumor-directed immune activation can be achieved by local injections of immune modulators in the tumor area or by directing the immune modulator to the tumor using bispecific antibodies. In this review, we focus on therapies targeting checkpoint inhibitors and co-stimulatory receptors that can generate tumor-specific T cell responses through localized immune activation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- Bispecific antibody
- Cancer
- Immuno-oncology
- Immunotherapy
- Intratumoral
- Tumor-directed immunotherapy
- Immunotherapy
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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