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A broad spectrum an...
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Rao, Komal UmashankarLund University,Lunds universitet,Medicinsk mikrobiologi,Forskargrupper vid Lunds universitet,Medical Microbiology,Lund University Research Groups,Lund Univ, Inst Lab Med, Dept Microbiol Immunol & Glycobiol, Lund, Sweden.,Lund University, Sweden
(author)
A broad spectrum anti-bacterial peptide with an adjunct potential for tuberculosis chemotherapy
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021-02-18
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Springer Science and Business Media LLC,2021
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:67b3dd8f-eadc-4e1f-b0e1-b87fbff134d7
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https://lup.lub.lu.se/record/67b3dd8f-eadc-4e1f-b0e1-b87fbff134d7URI
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https://doi.org/10.1038/s41598-021-83755-3DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-439933URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:ri:diva-52583URI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Open access funding provided by Lund University. NK, IGM and BR thank the UK Medical Research Council for support in the MRC Centre for Molecular Bacteriology and Infection, Imperial College London. The research was funded by the Swedish Heart–Lung Foundation (20200378), Alfred Österlunds Foundation, Royal Physiographic Society of Lund, Swedish Research Council and European Union’s Seventh Framework Programme (FP7/2007–2013) under grant agreement no 604182, FORMAMP-Innovative Nanoformulation of Antimicrobial Peptides to Treat Bacterial Infectious Diseases
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Alternative ways to prevent and treat infectious diseases are needed. Previously, we identified a fungal peptide, NZX, that was comparable to rifampicin in lowering M. tuberculosis load in a murine tuberculosis (TB) infection model. Here we assessed the potential synergy between this cationic host defence peptide (CHDP) and the current TB drugs and analysed its pharmacokinetics. We found additive effect of this peptide with isoniazid and ethambutol and confirmed these results with ethambutol in a murine TB-model. In vivo, the peptide remained stable in circulation and preserved lung structure better than ethambutol alone. Antibiotic resistance studies did not induce mutants with reduced susceptibility to the peptide. We further observed that this peptide was effective against nontuberculous mycobacteria (NTM), such as M. avium and M. abscessus, and several Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus. In conclusion, the presented data supports a role for this CHDP in the treatment of drug resistant organisms.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Henderson, Domhnall IainLund University, Sweden,Lund Univ, Inst Lab Med, Dept Microbiol Immunol & Glycobiol, Lund, Sweden.
(author)
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Krishnan, NityaImperial College London,Imperial Coll, Dept Infect Dis, MRC Ctr Mol Bacteriol & Infect, London, England.,Imperial College, UK
(author)
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Puthia, ManojLund University,Lunds universitet,Schmidtchen lab,Forskargrupper vid Lunds universitet,Schmidtchen Lab,Lund University Research Groups,Lund Univ, Inst Clin Sci, Dept Dermatol & Venereol, Lund, Sweden.,Lund University, Sweden(Swepub:lu)med-mpu
(author)
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Glegola-Madejska, IzabelaImperial College London,Imperial Coll, Dept Infect Dis, MRC Ctr Mol Bacteriol & Infect, London, England.,Imperial College, UK
(author)
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Brive, LenaRISE,Tillverkningsprocesser
(author)
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Bjarnemark, FannyRISE,Kemi, biomaterial och textil,Kemi och Tillämpad mekanik(Swepub:ri)fannybj@ri.se
(author)
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Millqvist-Fureby, AnnaRISE,Kemiska processer och läkemedel(Swepub:ri)AnnaFu@ri.se
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Hjort, KarinUppsala universitet,Uppsala University,Institutionen för medicinsk biokemi och mikrobiologi,Uppsala University, Sweden(Swepub:uu)khj03860
(author)
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Andersson, Dan I.Uppsala universitet,Uppsala University,Institutionen för medicinsk biokemi och mikrobiologi,Uppsala University, Sweden(Swepub:uu)dan19789
(author)
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Tenland, ErikLund University,Lunds universitet,Medicinsk mikrobiologi,Forskargrupper vid Lunds universitet,Medical Microbiology,Lund University Research Groups,Lund Univ, Inst Lab Med, Dept Microbiol Immunol & Glycobiol, Lund, Sweden.,Lund University, Sweden(Swepub:lu)med-ete
(author)
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Sturegård, ErikLund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups,Lund Univ, Inst Translat Med, Dept Clin Microbiol, Malmö, Sweden.,Lund University, Sweden(Swepub:lu)mmb-est
(author)
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Robertson, Brian D.Imperial College London,Imperial Coll, Dept Infect Dis, MRC Ctr Mol Bacteriol & Infect, London, England.,Imperial College, UK
(author)
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Godaly, GabrielaLund University,Lunds universitet,Medicinsk mikrobiologi,Forskargrupper vid Lunds universitet,Medical Microbiology,Lund University Research Groups,Lund Univ, Inst Lab Med, Dept Microbiol Immunol & Glycobiol, Lund, Sweden.,Lund University, Sweden(Swepub:lu)mmb-ggo
(author)
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Medicinsk mikrobiologiForskargrupper vid Lunds universitet
(creator_code:org_t)
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In:Scientific Reports: Springer Science and Business Media LLC11:12045-2322
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