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Transcriptome-wide ...
Transcriptome-wide association study of multiple myeloma identifies candidate susceptibility genes
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- Went, Molly (author)
- Institute of Cancer Research London
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- Kinnersley, Ben (author)
- Institute of Cancer Research London
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- Sud, Amit (author)
- Institute of Cancer Research London
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- Johnson, David C (author)
- Institute of Cancer Research London
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- Weinhold, Niels (author)
- Heidelberg University,University of Arkansas for Medical Sciences,University Hospital Heidelberg
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- Försti, Asta (author)
- German Cancer Research Centre
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- van Duin, Mark (author)
- Erasmus University Medical Center
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- Orlando, Giulia (author)
- Institute of Cancer Research London
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- Mitchell, Jonathan S (author)
- Institute of Cancer Research London
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- Kuiper, Rowan (author)
- Erasmus University Medical Center
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- Walker, Brian A. (author)
- University of Arkansas for Medical Sciences
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- Gregory, Walter M. (author)
- University of Leeds
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- Hoffmann, Per (author)
- University Hospital Bonn,University of Bonn,University of Basel
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- Jackson, Graham H. (author)
- Royal Victoria Infirmary
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- Nöthen, Markus M (author)
- University of Bonn,University Hospital Bonn
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- Inacio da Silva Filho, Miguel (author)
- German Cancer Research Centre
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- Thomsen, Hauke (author)
- German Cancer Research Centre
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- Broyl, Annemiek (author)
- Erasmus University Medical Center
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- Davies, Faith E. (author)
- University of Arkansas for Medical Sciences
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- Thorsteinsdottir, Unnur (author)
- Agricultural University of Iceland,deCODE Genetics,University of Iceland
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- Hansson, Markus (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Myelomgruppen,Forskargrupper vid Lunds universitet,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Myeloma research group,Lund University Research Groups,Skåne University Hospital
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- Kaiser, Martin (author)
- Royal Marsden Hospital, Sutton,Institute of Cancer Research London
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- Sonneveld, Pieter (author)
- Erasmus University Medical Center
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- Goldschmidt, Hartmut (author)
- Heidelberg University,National Centre of Tumor Diseases,German Cancer Research Centre,University Hospital Heidelberg
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- Stefansson, Kari (author)
- deCODE Genetics,Agricultural University of Iceland,National University Hospital of Iceland,University of Iceland
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- Hemminki, Kari (author)
- German Cancer Research Centre
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- Nilsson, Björn (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Hematogenomics,Forskargrupper vid Lunds universitet,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Lund University Research Groups,Broad Institute
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- Morgan, Gareth J. (author)
- University of Arkansas for Medical Sciences
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- Houlston, Richard S. (author)
- Institute of Cancer Research London
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(creator_code:org_t)
- 2019-08-20
- 2019
- English.
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In: Human Genomics. - : Springer Science and Business Media LLC. - 1479-7364. ; 13:1
- Related links:
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http://dx.doi.org/10... (free)
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https://humgenomics....
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- BackgroundWhile genome-wide association studies (GWAS) of multiple myeloma (MM) have identified variants at 23 regions influencing risk, the genes underlying these associations are largely unknown. To identify candidate causal genes at these regions and search for novel risk regions, we performed a multi-tissue transcriptome-wide association study (TWAS).ResultsGWAS data on 7319 MM cases and 234,385 controls was integrated with Genotype-Tissue Expression Project (GTEx) data assayed in 48 tissues (sample sizes, N = 80–491), including lymphocyte cell lines and whole blood, to predict gene expression. We identified 108 genes at 13 independent regions associated with MM risk, all of which were in 1 Mb of known MM GWAS risk variants. Of these, 94 genes, located in eight regions, had not previously been considered as a candidate gene for that locus.ConclusionsOur findings highlight the value of leveraging expression data from multiple tissues to identify candidate genes responsible for GWAS associations which provide insight into MM tumorigenesis. Among the genes identified, a number have plausible roles in MM biology, notably APOBEC3C, APOBEC3H, APOBEC3D, APOBEC3F, APOBEC3G, or have been previously implicated in other malignancies. The genes identified in this TWAS can be explored for follow-up and validation to further understand their role in MM biology.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Went, Molly
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Kinnersley, Ben
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Sud, Amit
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Johnson, David C
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Weinhold, Niels
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Försti, Asta
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show more...
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van Duin, Mark
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Orlando, Giulia
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Mitchell, Jonath ...
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Kuiper, Rowan
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Walker, Brian A.
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Gregory, Walter ...
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Hoffmann, Per
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Jackson, Graham ...
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Nöthen, Markus M
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Inacio da Silva ...
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Thomsen, Hauke
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Broyl, Annemiek
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Davies, Faith E.
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Thorsteinsdottir ...
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Hansson, Markus
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Kaiser, Martin
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Sonneveld, Piete ...
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Goldschmidt, Har ...
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Stefansson, Kari
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Hemminki, Kari
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Nilsson, Björn
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Morgan, Gareth J ...
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Houlston, Richar ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Human Genomics
- By the university
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Lund University