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Free heme and hemop...
Free heme and hemopexin in acute kidney injury after cardiopulmonary bypass and transient renal ischemia
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- Greite, Robert (author)
- Hannover Medical School
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- Schott, Sebastian (author)
- Hannover Medical School
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- Wang, Li (author)
- Hannover Medical School
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- Gohlke, Lukas (author)
- Hannover Medical School
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- Kreimann, Kirill (author)
- Hannover Medical School
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- Derlin, Katja (author)
- Hannover Medical School
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- Gutberlet, Marcel (author)
- Hannover Medical School
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- Schmidbauer, Martina (author)
- Hannover Medical School
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- Leffler, Andreas (author)
- Hannover Medical School
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- Tudorache, Igor (author)
- University Hospital of Düsseldorf
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- Salman, Jawad (author)
- Hannover Medical School
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- Ius, Fabio (author)
- Hannover Medical School
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- Natanov, Ruslan (author)
- Hannover Medical School
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- Fegbeutel, Christine (author)
- Hannover Medical School
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- Haverich, Axel (author)
- Hannover Medical School
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- Lichtinghagen, Ralf (author)
- Hannover Medical School
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- Hüsing, Anne M. (author)
- Hannover Medical School
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- von Vietinghoff, Sibylle (author)
- Hannover Medical School,University Hospital Bonn
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- Schmitt, Roland (author)
- Hannover Medical School
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- Shushakova, Nelli (author)
- Hannover Medical School
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- Rong, Song (author)
- Hannover Medical School
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- Haller, Hermann (author)
- Hannover Medical School
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- Schmidt-Ott, Kai M. (author)
- Hannover Medical School
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- Gram, Magnus (author)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Vijayan, Vijith (author)
- Hannover Medical School,Stanford University School of Medicine
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- Scheffner, Irina (author)
- Hannover Medical School
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- Gwinner, Wilfried (author)
- Hannover Medical School
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- Immenschuh, Stephan (author)
- Hannover Medical School
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: Clinical and Translational Science. - 1752-8054. ; 16:12, s. 2729-2743
- Related links:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Free heme is released from hemoproteins during hemolysis or ischemia reperfusion injury and can be pro-inflammatory. Most studies on nephrotoxicity of hemolysis-derived proteins focus on free hemoglobin (fHb) with heme as a prosthetic group. Measurement of heme in its free, non-protein bound, form is challenging and not commonly used in clinical routine diagnostics. In contrast to fHb, the role of free heme in acute kidney injury (AKI) after cardiopulmonary bypass (CPB) surgery is unknown. Using an apo-horseradish peroxidase-based assay, we identified free heme during CPB surgery as predictor of AKI in patients undergoing cardiac valve replacement (n = 37). Free heme levels during CPB surgery correlated with depletion of hemopexin (Hx), a heme scavenger-protein. In mice, the impact of high levels of circulating free heme on the development of AKI following transient renal ischemia and the therapeutic potential of Hx were investigated. C57BL/6 mice were subjected to bilateral renal ischemia/reperfusion injury for 15 min which did not cause AKI. However, additional administration of free heme in this model promoted overt AKI with reduced renal function, increased renal inflammation, and reduced renal perfusion on functional magnetic resonance imaging. Hx treatment attenuated AKI. Free heme administration to sham operated control mice did not cause AKI. In conclusion, free heme is a predictor of AKI in CPB surgery patients and promotes AKI in transient renal ischemia. Depletion of Hx in CPB surgery patients and attenuation of AKI by Hx in the in vivo model encourage further research on Hx therapy in patients with increased free heme levels during CPB surgery.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Greite, Robert
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Schott, Sebastia ...
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Wang, Li
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Gohlke, Lukas
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Kreimann, Kirill
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Derlin, Katja
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Gutberlet, Marce ...
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Schmidbauer, Mar ...
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Leffler, Andreas
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Tudorache, Igor
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Salman, Jawad
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Ius, Fabio
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Natanov, Ruslan
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Fegbeutel, Chris ...
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Haverich, Axel
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Lichtinghagen, R ...
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Hüsing, Anne M.
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von Vietinghoff, ...
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Schmitt, Roland
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Shushakova, Nell ...
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Rong, Song
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Haller, Hermann
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Schmidt-Ott, Kai ...
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Gram, Magnus
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Vijayan, Vijith
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Scheffner, Irina
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Gwinner, Wilfrie ...
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Immenschuh, Step ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Clinical and Tra ...
- By the university
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Lund University