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Lenalidomide-bendam...
Lenalidomide-bendamustine-rituximab in untreated mantle cell lymphoma > 65 years, the Nordic Lymphoma Group phase I+II trial NLG-MCL4
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- Albertsson-Lindblad, Alexandra (författare)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Kolstad, Arne (författare)
- Oslo university hospital
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- Laurell, Anna (författare)
- Uppsala University Hospital
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- Räty, Riikka (författare)
- Helsinki University Central Hospital
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- Grønbæk, Kirsten (författare)
- Copenhagen University Hospital
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- Sundberg, Jan (författare)
- Skåne University Hospital
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- Pedersen, Lone Bredo (författare)
- Copenhagen University Hospital
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- Ralfkiær, Elisabeth (författare)
- Copenhagen University Hospital
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- Karjalainen-Lindsberg, Marja-Liisa (författare)
- University of Helsinki,Helsinki University Central Hospital
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- Sundström, Christer (författare)
- Uppsala University
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- Ehinger, Mats (författare)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Geisler, Christian (författare)
- Copenhagen University Hospital
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- Jerkeman, Mats (författare)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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(creator_code:org_t)
- American Society of Hematology, 2016
- 2016
- Engelska.
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Ingår i: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 128:14, s. 1814-1820
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https://portal.resea... (primary) (free)
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http://dx.doi.org/10...
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https://ashpublicati...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- For elderly patients with mantle cell lymphoma (MCL), there is no defined standard therapy. In this multicenter open-label phase I/II trial we evaluated the addition of lenalidomide (LEN) to rituximab-bendamustine (R-B) as first-line treatment to elderly MCL patients. Patients >65 years with untreated MCL, stage II-IV were eligible for inclusion. Primary endpoints were maximally tolerable dose (MTD) of LEN, and progression-free survival (PFS). Patients received six cycles q4w of L-B-R (L D1-14, B 90 mg/m(2) iv D1-2 and R 375 mg/m(2) iv D1) followed by single LEN (D1-21, q4w, cycles 7-13). 51 patients (median age 71 years) were enrolled 2009-2013. In phase I, the MTD of LEN was defined as 10 mg in cycles 2-6, and omitted in cycle 1. After six cycles, the complete remission rate (CRR) was 64% and 36% were MRD negative. At a median follow-up time of 31 months, median PFS was 42 months and 3 year overall survival was 73%. Infection was the most common non-hematological grade 3-5 event and occurred in 21 (42%) patients. Opportunistic infections occurred in three patients; 2 PCP and 1 CMV retinitis. Second primary malignancies (SPM) were observed in eight patients (16%). LEN could safely be combined with R-B, when added from the second cycle in patients with MCL, and was associated with a high rate of CR and molecular remission. However, we observed a high degree of severe infections and an unexpected high number of SPMs which may limit its use. http://clinicaltrials.gov: NCT00963534.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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Albertsson-Lindb ...
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Kolstad, Arne
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Laurell, Anna
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Räty, Riikka
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Grønbæk, Kirsten
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Sundberg, Jan
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Pedersen, Lone B ...
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Ralfkiær, Elisab ...
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Karjalainen-Lind ...
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Sundström, Chris ...
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Ehinger, Mats
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Geisler, Christi ...
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Jerkeman, Mats
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