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The challenges of recruiting never-smokers with chronic obstructive pulmonary disease from the large population-based Swedish cardiopulmonary bioimage study (SCAPIS) cohort

Sönnerfors, Pernilla (author)
Respiratory Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Medical Unit Occupational Therapy and Physiotherapy, Women´s Health and Allied Health Professionals Theme, Karolinska University Hospital, Stockholm, Sweden
Jacobson, Petra Kristina (author)
Department of Respiratory Medicine in Linköping, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden
Andersson, Anders (author)
COPD Center, Department of Respiratory Medicine and Allergology, Sahlgrenska University Hospital, Gothenburg, Sweden; COPD Center Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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Behndig, Annelie, 1963- (author)
Umeå universitet,Institutionen för folkhälsa och klinisk medicin
Bjermer, Leif (author)
Department of Clinical Sciences, Respiratory medicine, Allergology and Palliative Medicine, Lund University, Lund, Sweden
Blomberg, Anders, 1961- (author)
Umeå universitet,Institutionen för folkhälsa och klinisk medicin
Blomqvist, Heléne (author)
Respiratory Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden
Erjefält, Jonas (author)
Unit of Airway inflammation, Department of Experimental Medicine Sciences, Lund University, Lund, Sweden
Sehlstedt, Maria, 1979- (author)
Umeå universitet,Institutionen för folkhälsa och klinisk medicin
Lamberg Lundström, Kristina (author)
Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden
Lundborg, Anna (author)
COPD Center, Department of Respiratory Medicine and Allergology, Sahlgrenska University Hospital, Gothenburg, Sweden
Malinovschi, Andrei (author)
Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden
Persson, Hans Lennart (author)
Department of Respiratory Medicine in Linköping, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden
Tufvesson, Ellen (author)
Department of Clinical Sciences, Respiratory medicine, Allergology and Palliative Medicine, Lund University, Lund, Sweden
Wheelock, Åsa (author)
Respiratory Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden
Janson, Christer (author)
Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden
Sköld, Carl Magnus (author)
Respiratory Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden
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 (creator_code:org_t)
Taylor & Francis, 2024
2024
English.
In: European Clinical Respiratory Journal. - : Taylor & Francis. - 2001-8525. ; 11:1
Related links:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
https://urn.kb.se/re...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Background: A substantial proportion of individuals with COPD have never smoked, and it is implied to be more common than previously anticipated but poorly studied.Aim: To describe the process of recruitment of never-smokers with COPD from a population-based cohort (n = 30 154).Methods: We recruited never-smokers with COPD, aged 50–75 years, from six University Hospitals, based on: 1) post broncho-dilator forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC) < 0.70 and 2) FEV1 50–100% of predicted value and 3) being never-smokers (self-reported). In total 862 SCAPIS participants were identified, of which 652 were reachable and agreed to a first screening by telephone. Altogether 128 (20%) were excluded due to previous smoking or declined participation. We also applied a lower limit of normal (LLN) of FEV1/FVC (z-score<-1.64) according to the Global Lung Initiative to ensure a stricter definition of airflow obstruction.Results: Data on respiratory symptoms, health status, and medical history were collected from 492 individuals, since 32 were excluded at a second data review (declined or previous smoking), prior to the first visit. Due to not matching the required lung function criteria at a second spirometry, an additional 334 (68%) were excluded. These exclusions were by reason of: FEV1/FVC ≥0.7 (49%), FEV1 > 100% of predicted (26%) or z-score ≥ −1,64 (24%). Finally, 154 never-smokers with COPD were included: 56 (36%) women, (mean) age 60 years, FEV1 84% of predicted, FEV1/FVC: 0.6, z-score: −2.2, Oxygen saturation: 97% and BMI: 26.8 kg/m2.Conclusions: The challenges of a recruitment process of never-smokers with COPD were shown, including the importance of correct spirometry testing and strict inclusion criteria. Our findings highlight the importance of repeated spirometry assessments for improved accuracy in diagnosing COPD.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)

Keyword

COPD
COPD diagnosis
never-smokers
population-based
recruitment
SCAPIS
spirometry

Publication and Content Type

ref (subject category)
art (subject category)

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