A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort

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Bossini-Castillo, Lara (author)

A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort

Article/chapterEnglish2011

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2010-12-27
BMJ,2011

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LIBRIS-ID:oai:lup.lub.lu.se:68e5ee38-bc36-4f42-a894-94ffc11e8174
https://lup.lub.lu.se/record/1868682URI
https://doi.org/10.1136/ard.2010.141838DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:122131480URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

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Objectives The aim of this study was to confirm the influence of TNFSF4 polymorphisms on systemic sclerosis (SSc) susceptibility and phenotypic features. Methods A total of 8 European populations of Caucasian ancestry were included, comprising 3014 patients with SSc and 3125 healthy controls. Four genetic variants of TNFSF4 gene promoter (rs1234314, rs844644, rs844648 and rs12039904) were selected as genetic markers. Results A pooled analysis revealed the association of rs1234314 and rs12039904 polymorphisms with SSc (OR 1.15, 95% CI 1.02 to 1.31; OR 1.18, 95% CI 1.08 to 1.29, respectively). Significant association of the four tested variants with patients with limited cutaneous SSc (lcSSc) was revealed (rs1234314 OR 1.22, 95% CI 1.07 to 1.38; rs844644 OR 0.91, 95% CI 0.83 to 0.99; rs844648 OR 1.10, 95% CI 1.01 to 1.20 and rs12039904 OR 1.20, 95% CI 1.09 to 1.33). Association of rs1234314, rs844648 and rs12039904 minor alleles with patients positive for anti-centromere antibodies (ACA) remained significant (OR 1.23, 95% CI 1.10 to 1.37; OR 1.12, 95% CI 1.01 to 1.25; OR 1.22, 95% CI 1.07 to 1.38, respectively). Haplotype analysis confirmed a protective haplotype associated with SSc, lcSSc and ACA positive subgroups (OR 0.88, 95% CI 0.82 to 0.96; OR 0.88, 95% CI 0.80 to 0.96; OR 0.86, 95% CI 0.77 to 0.97, respectively) and revealed a new risk haplotype associated with the same groups of patients (OR 1.14, 95% CI 1.03 to 1.26; OR 1.20, 95% CI 1.08 to 1.35; OR 1.23, 95% CI 1.07 to 1.42, respectively). Conclusions The data confirm the influence of TNFSF4 polymorphisms in SSc genetic susceptibility, especially in subsets of patients positive for lcSSc and ACA.

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Broen, Jasper C. A. (author)
Simeon, Carmen P. (author)
Beretta, Lorenzo (author)
Vonk, Madelon C. (author)
Ortego-Centeno, Norberto (author)
Espinosa, Gerard (author)
Carreira, Patricia (author)
Teresa Camps, Maria (author)
Navarrete, Nuria (author)
Gonzalez-Escribano, Maria F. (author)
Vicente-Rabaneda, Esther (author)
Rodriguez, Luis (author)
Tolosa, Carlos (author)
Roman-Ivorra, Jose A. (author)
Gomez-Gracia, Inmaculada (author)
Garcia-Hernandez, Francisco J. (author)
Castellvi, Ivan (author)
Gallego, Maria (author)
Fernandez-Nebro, Antonio (author)
Garcia-Portales, Rosa (author)
Victoria Egurbide, Maria (author)
Fonollosa, Vicente (author)
Garcia de la Pena, Paloma (author)
Pros, Ana (author)
Gonzalez-Gay, Miguel A. (author)
Hesselstrand, RogerLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-rhe (author)
Riemekasten, Gabriela (author)
Witte, Torsten (author)
Coenen, Marieke J. H. (author)
Koeleman, Bobby P. (author)
Houssiau, Frederic (author)
Smith, Vanessa (author)
de Keyser, Filip (author)
Westhovens, Rene (author)
De Langhe, Ellen (author)
Voskuyl, Alexandre E. (author)
Schuerwegh, Annemie J. (author)
Chee, Meng May (author)
Madhok, Rajan (author)
Shiels, Paul (author)
Fonseca, Carmen (author)
Denton, Christopher (author)
Claes, Kathleen (author)
Padykov, LeonidKarolinska Institutet (author)
Nordin, AnnikaKarolinska Institutet (author)
Palm, Oyvind (author)
Lie, Benedicte A. (author)
Airo, Paolo (author)
Scorza, Raffaella (author)
van Laar, Jacob M. (author)
Hunzelmann, Nicolas (author)
Kreuter, Alexander (author)
Herrick, Ariane (author)
Worthington, Jane (author)
Radstake, Timothy R. D. J. (author)
Martin, Javier (author)
Rueda, Blanca (author)
Reumatologi och molekylär skelettbiologiSektion III (creator_code:org_t)

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In:Annals of the Rheumatic Diseases: BMJ70:4, s. 638-6411468-20600003-4967

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By the author/editor: Bossini-Castillo ...; Broen, Jasper C. ...; Simeon, Carmen P ...; Beretta, Lorenzo; Vonk, Madelon C.; Ortego-Centeno, ...; show more...; Espinosa, Gerard; Carreira, Patric ...; Teresa Camps, Ma ...; Navarrete, Nuria; Gonzalez-Escriba ...; Vicente-Rabaneda ...; Rodriguez, Luis; Tolosa, Carlos; Roman-Ivorra, Jo ...; Gomez-Gracia, In ...; Garcia-Hernandez ...; Castellvi, Ivan; Gallego, Maria; Fernandez-Nebro, ...; Garcia-Portales, ...; Victoria Egurbid ...; Fonollosa, Vicen ...; Garcia de la Pen ...; Pros, Ana; Gonzalez-Gay, Mi ...; Hesselstrand, Ro ...; Riemekasten, Gab ...; Witte, Torsten; Coenen, Marieke ...; Koeleman, Bobby ...; Houssiau, Freder ...; Smith, Vanessa; de Keyser, Filip; Westhovens, Rene; De Langhe, Ellen; Voskuyl, Alexand ...; Schuerwegh, Anne ...; Chee, Meng May; Madhok, Rajan; Shiels, Paul; Fonseca, Carmen; Denton, Christop ...; Claes, Kathleen; Padykov, Leonid; Nordin, Annika; Palm, Oyvind; Lie, Benedicte A ...; Airo, Paolo; Scorza, Raffaell ...; van Laar, Jacob ...; Hunzelmann, Nico ...; Kreuter, Alexand ...; Herrick, Ariane; Worthington, Jan ...; Radstake, Timoth ...; Martin, Javier; Rueda, Blanca; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Rheumatology and ...

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