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The association of ...
The association of meniscal damage with joint effusion in persons without radiographic osteoarthritis: the Framingham and MOST osteoarthritis studies
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Roemer, F. W. (author)
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Guermazi, A. (author)
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Hunter, D. J. (author)
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Niu, J. (author)
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Zhang, Y. (author)
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- Englund, Martin (author)
- Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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Javaid, M. K. (author)
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Lynch, J. A. (author)
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Mohr, A. (author)
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Torner, J. (author)
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Lewis, C. E. (author)
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Nevitt, M. C. (author)
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Felson, D. T. (author)
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(creator_code:org_t)
- Elsevier BV, 2009
- 2009
- English.
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In: Osteoarthritis and Cartilage. - : Elsevier BV. - 1063-4584. ; 17:6, s. 748-753
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Abstract
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- Objective: To assess the cross-sectional association between meniscal status and joint effusion on magnetic resonance imaging (MRI) in knees without radiographic osteoarthritis (OA). Design: Knees without OA (Kellgren/Lawrence grade 0) from the Framingham and MOST studies were examined by MRI. Meniscal status was assessed with a score of 0-4 in the anterior horn/body/posterior horn of the medial/lateral meniscus and effusion was assessed using a score of 0-3. The odds ratios (ORs) of joint effusion in those with meniscal damage were estimated using a logistic regression model. A sub-analysis was performed for knees without MRI-detected cartilage damage. Results: Of 1368 knees, 296 (21.6%) showed meniscal pathology in at least one subregion. Effusion was present in 133 (44.9%) of knees with meniscal damage vs 328 (30.6%) in those without meniscal damage. The adjusted OR of effusion in a knee with meniscal damage was 1.8, 95% confidence intervals (CI) [1.4, 2.4]. The OR of effusion for the group with meniscal pathology in two compartments was 5.4, 95% CI [2.1, 14.3]. For knees without any cartilage lesions but with meniscal damage in any compartment the OR was 2.3, 95% CI [1.1, 4.5]. Conclusions: Knees without OA but with meniscal pathology exhibit joint effusion to a significantly higher degree than knees without meniscal damage. The association persists for knees without cartilage damage. The prevalence of effusion is further increased when present in two compartments. Concomitant occurrence of synovial activation and meniscal damage contributes to understanding the pathophysiology of early degenerative joint disease. (C) 2008 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- Meniscal tear
- Magnetic resonance imaging
- Effusion
- Osteoarthritis
- Knee
- Synovium
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Roemer, F. W.
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Guermazi, A.
-
Hunter, D. J.
-
Niu, J.
-
Zhang, Y.
-
Englund, Martin
-
show more...
-
Javaid, M. K.
-
Lynch, J. A.
-
Mohr, A.
-
Torner, J.
-
Lewis, C. E.
-
Nevitt, M. C.
-
Felson, D. T.
-
show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Osteoarthritis a ...
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Lund University